Mina, an Il4 Repressor, Controls T Helper Type 2 Bias

Overview

Journal Nat Immunol

Date 2009 Jun 30

PMID 19561615

Citations 31

Authors

Mariko Okamoto

Melanie Van Stry

Linda Chung

Madoka Koyanagi

Xizhang Sun

Yoshie Suzuki

Osamu Ohara

Hiroshi Kitamura

Atsushi Hijikata

Masato Kubo

Mark Bix

Affiliations

Soon will be listed here.

Abstract

T helper type 2 (T(H)2) bias, which is the propensity of naive CD4(+) T cells to differentiate into interleukin 4 (IL-4)-secreting T(H)2 cells, is a genetic trait that affects susceptibility to infectious, autoimmune and allergic diseases. T(H)2 bias correlates with the amount of IL-4 initially secreted by newly activated helper T cells that feeds back positively through the pathway of the IL-4 receptor and the transcription factors STAT6 and GATA-3 to drive T(H)2 development. Here we identify Mina, a member of the jumonji C (JmjC) protein family, as a genetic determinant of T(H)2 bias. Mina specifically bound to and repressed the Il4 promoter. Mina overexpression in transgenic mice impaired Il4 expression, whereas its knockdown in primary CD4(+) T cells led to Il4 derepression. Our findings collectively provide mechanistic insight into an Il4-regulatory pathway that controls helper T cell differentiation and genetic variation in T(H)2 bias.

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