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Active Conservation of Noncoding Sequences Revealed by Three-way Species Comparisons

Overview
Journal Genome Res
Specialty Genetics
Date 2000 Sep 14
PMID 10984448
Citations 122
Authors
I Dubchak
M Brudno
G G Loots
L Pachter
C Mayor
E M Rubin
K A Frazer
Affiliations
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Abstract

Human and mouse genomic sequence comparisons are being increasingly used to search for evolutionarily conserved gene regulatory elements. Large-scale human-mouse DNA comparison studies have discovered numerous conserved noncoding sequences of which only a fraction has been functionally investigated A question therefore remains as to whether most of these noncoding sequences are conserved because of functional constraints or are the result of a lack of divergence time.

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