Fibrotic Disease and the T(H)1/T(H)2 Paradigm

Overview

Journal Nat Rev Immunol

Specialty Allergy & Immunology

Date 2004 Aug 3

PMID 15286725

Citations 738

Authors

Thomas A Wynn

Affiliations

Soon will be listed here.

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References

Zhu Z, Homer R, Wang Z, Chen Q, Geba G, Wang J . Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J Clin Invest. 1999; 103(6):779-88. PMC: 408149. DOI: 10.1172/JCI5909. View

Le Moine A, Flamand V, Demoor F, Noel J, Surquin M, Kiss R . Critical roles for IL-4, IL-5, and eosinophils in chronic skin allograft rejection. J Clin Invest. 1999; 103(12):1659-67. PMC: 408380. DOI: 10.1172/JCI5504. View

Munder M, Eichmann K, Moran J, Centeno F, Soler G, Modolell M . Th1/Th2-regulated expression of arginase isoforms in murine macrophages and dendritic cells. J Immunol. 1999; 163(7):3771-7. View

Chiaramonte M, Donaldson D, CHEEVER A, Wynn T . An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response. J Clin Invest. 1999; 104(6):777-85. PMC: 408441. DOI: 10.1172/JCI7325. View

Randolph D, Stephens R, Carruthers C, Chaplin D . Cooperation between Th1 and Th2 cells in a murine model of eosinophilic airway inflammation. J Clin Invest. 1999; 104(8):1021-9. PMC: 408580. DOI: 10.1172/JCI7631. View

Munger J, Huang X, Kawakatsu H, Griffiths M, Dalton S, Wu J . The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis. Cell. 1999; 96(3):319-28. DOI: 10.1016/s0092-8674(00)80545-0. View

Hesse M, Piccirillo C, Belkaid Y, Prufer J, Mentink-Kane M, Leusink M . The pathogenesis of schistosomiasis is controlled by cooperating IL-10-producing innate effector and regulatory T cells. J Immunol. 2004; 172(5):3157-66. DOI: 10.4049/jimmunol.172.5.3157. View

Wynn T, Hesse M, Sandler N, Kaviratne M, Hoffmann K, Chiaramonte M . P-selectin suppresses hepatic inflammation and fibrosis in mice by regulating interferon gamma and the IL-13 decoy receptor. Hepatology. 2004; 39(3):676-87. DOI: 10.1002/hep.20102. View

Kaviratne M, Hesse M, Leusink M, Cheever A, Davies S, McKerrow J . IL-13 activates a mechanism of tissue fibrosis that is completely TGF-beta independent. J Immunol. 2004; 173(6):4020-9. DOI: 10.4049/jimmunol.173.6.4020. View

10.

Clark J, Dedon T, Wayner E, Carter W . Effects of interferon-gamma on expression of cell surface receptors for collagen and deposition of newly synthesized collagen by cultured human lung fibroblasts. J Clin Invest. 1989; 83(5):1505-11. PMC: 303854. DOI: 10.1172/JCI114045. View

11.

Sher A, Coffman R, Hieny S, Scott P, CHEEVER A . Interleukin 5 is required for the blood and tissue eosinophilia but not granuloma formation induced by infection with Schistosoma mansoni. Proc Natl Acad Sci U S A. 1990; 87(1):61-5. PMC: 53199. DOI: 10.1073/pnas.87.1.61. View

12.

Emura M, NAGAI S, Takeuchi M, Kitaichi M, Izumi T . In vitro production of B cell growth factor and B cell differentiation factor by peripheral blood mononuclear cells and bronchoalveolar lavage T lymphocytes from patients with idiopathic pulmonary fibrosis. Clin Exp Immunol. 1990; 82(1):133-9. PMC: 1535146. DOI: 10.1111/j.1365-2249.1990.tb05416.x. View

13.

Fertin C, Nicolas J, Gillery P, Kalis B, Banchereau J, Maquart F . Interleukin-4 stimulates collagen synthesis by normal and scleroderma fibroblasts in dermal equivalents. Cell Mol Biol. 1991; 37(8):823-9. View

14.

Border W, Noble N, Yamamoto T, Harper J, Yamaguchi Y, Pierschbacher M . Natural inhibitor of transforming growth factor-beta protects against scarring in experimental kidney disease. Nature. 1992; 360(6402):361-4. DOI: 10.1038/360361a0. View

15.

Kulkarni A, Huh C, Becker D, Geiser A, Lyght M, Flanders K . Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death. Proc Natl Acad Sci U S A. 1993; 90(2):770-4. PMC: 45747. DOI: 10.1073/pnas.90.2.770. View

16.

Hogaboam C, Gallinat C, Chensue S, Lukacs N, Strieter R, Kunkel S . Collagen deposition in a non-fibrotic lung granuloma model after nitric oxide inhibition. Am J Pathol. 1998; 153(6):1861-72. PMC: 1866342. DOI: 10.1016/S0002-9440(10)65700-8. View

17.

Wills-Karp M, Luyimbazi J, Xu X, Schofield B, Neben T, Karp C . Interleukin-13: central mediator of allergic asthma. Science. 1998; 282(5397):2258-61. DOI: 10.1126/science.282.5397.2258. View

18.

Grunig G, Warnock M, Wakil A, Venkayya R, Brombacher F, Rennick D . Requirement for IL-13 independently of IL-4 in experimental asthma. Science. 1998; 282(5397):2261-3. PMC: 3897229. DOI: 10.1126/science.282.5397.2261. View

19.

Hansen G, Berry G, DeKruyff R, Umetsu D . Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation. J Clin Invest. 1999; 103(2):175-83. PMC: 407883. DOI: 10.1172/JCI5155. View

20.

Cho J, Miller M, Baek K, Han J, Nayar J, Lee S . Inhibition of airway remodeling in IL-5-deficient mice. J Clin Invest. 2004; 113(4):551-60. PMC: 338264. DOI: 10.1172/JCI19133. View