Phosphoproteomics and Cancer Research

Overview

Journal Clin Transl Oncol

Specialty Oncology

Date 2009 Jun 18

PMID 19531450

Citations 16

Authors

Keith Ashman

Elena Lopez Villar

Affiliations

Soon will be listed here.

Abstract

Protein phosphorylation plays key roles in the regulation of normal and cancer cells. It is a highly dynamic process. Protein kinases are the targets of several new cancer drugs and drug candidates. However, some of the main issues related to new drugs are how they function and the selection of those patients that will likely respond best to a particular treatment regime. There is an urgent need to understand and monitor kinase signalling pathways. Phosphoproteomics requires the enrichment of phosphorylated proteins or peptides from tissue or bodily fluids, and the application of technologies such as mass spectrometry (MS) to the identification and quantification of protein phosphorylation sites. As the field develops it will provide pharmacodynamic readouts of disease states and cellular drug responses in tumour samples. There have been a number of recent advances, but there are still technical hurdles and bioinformatics challenges that need to be addressed.

Citing Articles

Phosphoprotein Detection in Sweat Realized by Intercalation Structure 2D@3D g-CN@FeO Wearable Sensitive Motif.

Qiao Y, Qiao L, Zhao P, Zhang P, Wu F, Zhang J Biosensors (Basel). 2022; 12(6).

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Recent Advances of Functional Proteomics in Gastrointestinal Cancers- a Path towards the Identification of Candidate Diagnostic, Prognostic, and Therapeutic Molecular Biomarkers.

Abyadeh M, Meyfour A, Gupta V, Moghaddam M, Fitzhenry M, Shahbazian S Int J Mol Sci. 2020; 21(22).

PMID: 33198323 PMC: 7697099. DOI: 10.3390/ijms21228532.

Immobilization of a Ce(IV)-substituted polyoxometalate on ethylenediamine-functionalized graphene oxide for selective extraction of phosphoproteins.

Wang M, Chen S, Zhang D, Yu Y, Wang J Mikrochim Acta. 2018; 185(12):553.

PMID: 30456423 DOI: 10.1007/s00604-018-3095-9.

Phosphoproteomics of Retinoblastoma: A Pilot Study Identifies Aberrant Kinases.

Nagarajha Selvan L, Danda R, Madugundu A, Puttamallesh V, Sathe G, Krishnan U Molecules. 2018; 23(6).

PMID: 29914080 PMC: 6100359. DOI: 10.3390/molecules23061454.

Magnetic microspheres modified with Ti(IV) and Nb(V) for enrichment of phosphopeptides.

Jiang J, Sun X, She X, Li J, Li Y, Deng C Mikrochim Acta. 2018; 185(6):309.

PMID: 29802452 DOI: 10.1007/s00604-018-2837-z.

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