Expression of a Family of Noncoding Mitochondrial RNAs Distinguishes Normal from Cancer Cells

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2009 May 28

PMID 19470459

Citations 72

Authors

Veronica A Burzio

Claudio Villota

Jaime Villegas

Eduardo Landerer

Enrique Boccardo

Luisa L Villa

Ronny Martinez

Constanza Lopez

Fancy Gaete

Viviana Toro

Ximena Rodriguez

Luis O Burzio

Affiliations

Soon will be listed here.

Abstract

We reported the presence in human cells of a noncoding mitochondrial RNA that contains an inverted repeat (IR) of 815 nucleotides (nt) covalently linked to the 5' end of the mitochondrial 16S RNA (16S mtrRNA). The transcript contains a stem-loop structure and is expressed in human proliferating cells but not in resting cells. Here, we demonstrate that, in addition to this transcript, normal human proliferating cells in culture express 2 antisense mitochondrial transcripts. These transcripts also contain stem-loop structures but strikingly they are down-regulated in tumor cell lines and tumor cells present in 17 different tumor types. The differential expression of these transcripts distinguishes normal from tumor cells and might contribute a unique vision on cancer biology and diagnostics.

Citing Articles

LNC-ing Genetics in Mitochondrial Disease.

Kamps R, Robinson E Noncoding RNA. 2024; 10(6).

PMID: 39585049 PMC: 11587075. DOI: 10.3390/ncrna10060057.

Non-Coding RNAs of Mitochondrial Origin: Roles in Cell Division and Implications in Cancer.

Piergentili R, Sechi S Int J Mol Sci. 2024; 25(13).

PMID: 39000605 PMC: 11242419. DOI: 10.3390/ijms25137498.

Mitochondrion-to-nucleus communication mediated by RNA export: a survey of potential mechanisms and players across eukaryotes.

Muneretto G, Plazzi F, Passamonti M Biol Lett. 2024; 20(7):20240147.

PMID: 38982851 PMC: 11283861. DOI: 10.1098/rsbl.2024.0147.

Knockdown of Antisense Noncoding Mitochondrial RNA Reduces Tumorigenicity of Patient-Derived Clear Cell Renal Carcinoma Cells in an Orthotopic Xenograft Mouse Model.

Araya M, Sepulveda F, Villegas J, Alarcon L, Burzio L, Burzio V Cancers (Basel). 2024; 16(4).

PMID: 38398221 PMC: 10886546. DOI: 10.3390/cancers16040830.

Human mtDNA-Encoded Long ncRNAs: Knotty Molecules and Complex Functions.

Bruni F Int J Mol Sci. 2024; 25(3).

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