Proposed Mechanism for H(II) Phase Induction by Gramicidin in Model Membranes and Its Relation to Channel Formation

Overview

Journal Biophys J

Publisher Cell Press

Specialty Biophysics

Date 2009 May 12

PMID 19431714

Citations 10

Authors

J A Killian

B de Kruijff

Affiliations

Soon will be listed here.

Abstract

A model is proposed for the molecular mechanism of H(II) phase induction by gramicidin in model membranes. The model describes the sequence of events that occurs upon hydration of a mixed lipid/gramicidin film, relating them to gramicidin channel formation and to relevant literature on gramicidin and lipid structure.

Citing Articles

Lipid-gramicidin interactions: dynamic structure of the boundary lipid by 2D-ELDOR.

Costa-Filho A, Crepeau R, Borbat P, Ge M, Freed J Biophys J. 2003; 84(5):3364-78.

PMID: 12719265 PMC: 1302896. DOI: 10.1016/S0006-3495(03)70060-5.

Molecular theory of lipid-protein interaction and the Lalpha-HII transition.

May S, Ben-Shaul A Biophys J. 1999; 76(2):751-67.

PMID: 9929479 PMC: 1300079. DOI: 10.1016/S0006-3495(99)77241-3.

Electron-spin resonance study of aggregation of gramicidin in dipalmitoylphosphatidylcholine bilayers and hydrophobic mismatch.

Ge M, Freed J Biophys J. 1999; 76(1 Pt 1):264-80.

PMID: 9876140 PMC: 1302517. DOI: 10.1016/S0006-3495(99)77195-X.

Modulation of melittin-induced lysis by surface charge density of membranes.

Monette M, LaFleur M Biophys J. 1995; 68(1):187-95.

PMID: 7711241 PMC: 1281676. DOI: 10.1016/S0006-3495(95)80174-8.

X-ray scattering with momentum transfer in the plane of membrane. Application to gramicidin organization.

He K, Ludtke S, Wu Y, Huang H Biophys J. 1993; 64(1):157-62.

PMID: 7679294 PMC: 1262312. DOI: 10.1016/S0006-3495(93)81350-X.

References

Mazet J, Andersen O, Koeppe 2nd R . Single-channel studies on linear gramicidins with altered amino acid sequences. A comparison of phenylalanine, tryptophane, and tyrosine substitutions at positions 1 and 11. Biophys J. 1984; 45(1):263-76. PMC: 1435278. DOI: 10.1016/S0006-3495(84)84153-3. View

Tournois H, Haest C, de Gier J, de Kruijff B . Gramicidin-induced hexagonal HII phase formation in erythrocyte membranes. Biochemistry. 1987; 26(21):6613-21. DOI: 10.1021/bi00395a008. View

Prasad K, Trapane T, Busath D, Szabo G, Urry D . Synthesis and characterization of (1-13C) Phe9 gramicidin A. Effects of side chain variations. Int J Pept Protein Res. 1983; 22(3):341-7. DOI: 10.1111/j.1399-3011.1983.tb02100.x. View

Paulus H, Sarkar N, Mukherjee P, Langley D, Ivanov V, Shepel E . Comparison of the effect of linear gramicidin analogues on bacterial sporulation, membrane permeability, and ribonucleic acid polymerase. Biochemistry. 1979; 18(21):4532-6. DOI: 10.1021/bi00588a012. View

Buldt G, Gally H, Seelig A, Seelig J, Zaccai G . Neutron diffraction studies on selectively deuterated phospholipid bilayers. Nature. 1978; 271(5641):182-4. DOI: 10.1038/271182a0. View

Elliott J, Needham D, Dilger J, Haydon D . The effects of bilayer thickness and tension on gramicidin single-channel lifetime. Biochim Biophys Acta. 1983; 735(1):95-103. DOI: 10.1016/0005-2736(83)90264-x. View

Brasseur R, Killian J, de Kruijff B, Ruysschaert J . Conformational analysis of gramicidin-gramicidin interactions at the air/water interface suggests that gramicidin aggregates into tube-like structures similar as found in the gramicidin-induced hexagonal HII phase. Biochim Biophys Acta. 1987; 903(1):11-7. DOI: 10.1016/0005-2736(87)90150-7. View

Katz E, DEMAIN A . The peptide antibiotics of Bacillus: chemistry, biogenesis, and possible functions. Bacteriol Rev. 1977; 41(2):449-74. PMC: 414008. DOI: 10.1128/br.41.2.449-474.1977. View

Chapman D, Cornell B, Ellasz A, Perry A . Interactions of helical polypepetide segments which span the hydrocarbon region of lipid bilayers. Studies of the gramicidin A lipid-water system. J Mol Biol. 1977; 113(3):517-38. DOI: 10.1016/0022-2836(77)90236-4. View

10.

Tate M, Gruner S . Lipid polymorphism of mixtures of dioleoylphosphatidylethanolamine and saturated and monounsaturated phosphatidylcholines of various chain lengths. Biochemistry. 1987; 26(1):231-6. DOI: 10.1021/bi00375a031. View

11.

Veatch W, Fossel E, BLOUT E . The conformation of gramicidin A. Biochemistry. 1974; 13(26):5249-56. DOI: 10.1021/bi00723a001. View

12.

Urry D, Trapane T, Prasad K . Is the gramicidin a transmembrane channel single-stranded or double-stranded helix? A simple unequivocal determination. Science. 1983; 221(4615):1064-7. DOI: 10.1126/science.221.4615.1064. View

13.

Killian J, van den Berg C, Tournois H, Keur S, Slotboom A, van Scharrenburg G . Gramicidin-induced hexagonal HII phase formation in negatively charged phospholipids and the effect of N- and C-terminal modification of gramicidin on its interaction with zwitterionic phospholipids. Biochim Biophys Acta. 1986; 857(1):13-27. DOI: 10.1016/0005-2736(86)90094-5. View

14.

Haigh E, Thulborn K, Sawyer W . Comparison of fluorescence energy transfer and quenching methods to establish the position and orientation of components within the transverse plane of the lipid bilayer. Application to the gramicidin A--bilayer interaction. Biochemistry. 1979; 18(16):3525-32. DOI: 10.1021/bi00583a014. View

15.

Young M, MANDELSTAM J . Early events during bacterial endospore formation. Adv Microb Physiol. 1979; 20:103-62, 321-3. DOI: 10.1016/s0065-2911(08)60207-6. View

16.

Killian J, Burger K, de Kruijff B . Phase separation and hexagonal HII phase formation by gramicidins A, B and C in dioleoylphosphatidylcholine model membranes. A study on the role of the tryptophan residues. Biochim Biophys Acta. 1987; 897(2):269-84. DOI: 10.1016/0005-2736(87)90423-8. View

17.

Weinstein S, Wallace B, BLOUT E, Morrow J, Veatch W . Conformation of gramicidin A channel in phospholipid vesicles: a 13C and 19F nuclear magnetic resonance study. Proc Natl Acad Sci U S A. 1979; 76(9):4230-4. PMC: 411546. DOI: 10.1073/pnas.76.9.4230. View

18.

Killian J, de Kruijff B, Van Echteld C, Verkleij A, de Gier J . Mixtures of gramicidin and lysophosphatidylcholine form lamellar structures. Biochim Biophys Acta. 1983; 728(1):141-4. DOI: 10.1016/0005-2736(83)90446-7. View

19.

Kolb H, Bamberg E . Influence of membrane thickness and ion concentration on the properties of the gramicidin a channel. Autocorrelation, spectral power density, relaxation and single-channel studies. Biochim Biophys Acta. 1977; 464(1):127-41. DOI: 10.1016/0005-2736(77)90376-5. View

20.

Killian J, de Kruijff B . The influence of proteins and peptides on the phase properties of lipids. Chem Phys Lipids. 1986; 40(2-4):259-84. DOI: 10.1016/0009-3084(86)90073-3. View