Bursting of Sensitive Polymersomes Induced by Curling

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2009 Apr 23

PMID 19383800

Citations 23

Authors

Elyes Mabrouk

Damien Cuvelier

Francoise Brochard-Wyart

Pierre Nassoy

Min-Hui Li

Affiliations

Soon will be listed here.

Abstract

Polymersomes, which are stable and robust vesicles made of block copolymer amphiphiles, are good candidates for drug carriers or micro/nanoreactors. Polymer chemistry enables almost unlimited molecular design of responsive polymersomes whose degradation upon environmental changes has been used for the slow release of active species. Here, we propose a strategy to remotely trigger instantaneous polymersome bursting. We have designed asymmetric polymer vesicles, in which only one leaflet is composed of responsive polymers. In particular, this approach has been successfully achieved by using a UV-sensitive liquid-crystalline copolymer. We study experimentally and theoretically this bursting mechanism and show that it results from a spontaneous curvature of the membrane induced by the remote stimulus. The versatility of this mechanism should broaden the range of applications of polymersomes in fields such as drug delivery, cosmetics and material chemistry.

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References

Cerritelli S, Velluto D, Hubbell J . PEG-SS-PPS: reduction-sensitive disulfide block copolymer vesicles for intracellular drug delivery. Biomacromolecules. 2007; 8(6):1966-72. DOI: 10.1021/bm070085x. View

Rodriguez-Hernandez J, Lecommandoux S . Reversible inside-out micellization of pH-responsive and water-soluble vesicles based on polypeptide diblock copolymers. J Am Chem Soc. 2005; 127(7):2026-7. DOI: 10.1021/ja043920g. View

Evans E, Heinrich V, Ludwig F, Rawicz W . Dynamic tension spectroscopy and strength of biomembranes. Biophys J. 2003; 85(4):2342-50. PMC: 1303459. DOI: 10.1016/S0006-3495(03)74658-X. View

Discher B, Won Y, Ege D, Lee J, Bates F, Discher D . Polymersomes: tough vesicles made from diblock copolymers. Science. 1999; 284(5417):1143-6. DOI: 10.1126/science.284.5417.1143. View

Bellomo E, Wyrsta M, Pakstis L, Pochan D, Deming T . Stimuli-responsive polypeptide vesicles by conformation-specific assembly. Nat Mater. 2004; 3(4):244-8. DOI: 10.1038/nmat1093. View

Sandre O, Moreaux L, Brochard-Wyart F . Dynamics of transient pores in stretched vesicles. Proc Natl Acad Sci U S A. 1999; 96(19):10591-6. PMC: 17927. DOI: 10.1073/pnas.96.19.10591. View

Ghoroghchian P, Li G, Levine D, Davis K, Bates F, Hammer D . Bioresorbable Vesicles Formed through Spontaneous Self-Assembly of Amphiphilic Poly(ethylene oxide)-block-polycaprolactone. Macromolecules. 2011; 39(5):1673-1675. PMC: 2958688. DOI: 10.1021/ma0519009. View

Pautot S, Frisken B, Weitz D . Engineering asymmetric vesicles. Proc Natl Acad Sci U S A. 2003; 100(19):10718-21. PMC: 196870. DOI: 10.1073/pnas.1931005100. View

Borchert U, Lipprandt U, Bilang M, Kimpfler A, Rank A, Peschka-Suss R . pH-induced release from P2VP-PEO block copolymer vesicles. Langmuir. 2006; 22(13):5843-7. DOI: 10.1021/la060227t. View

10.

Aranda-Espinoza H, Bermudez H, Bates F, Discher D . Electromechanical limits of polymersomes. Phys Rev Lett. 2001; 87(20):208301. DOI: 10.1103/PhysRevLett.87.208301. View

11.

Chiu H, Lin Y, Huang Y, Chuang C, Chern C . Polymer vesicles containing small vesicles within interior aqueous compartments and pH-responsive transmembrane channels. Angew Chem Int Ed Engl. 2008; 47(10):1875-8. DOI: 10.1002/anie.200704078. View

12.

Johnson J, Ha T, Chu S, Boxer S . Early steps of supported bilayer formation probed by single vesicle fluorescence assays. Biophys J. 2002; 83(6):3371-9. PMC: 1302412. DOI: 10.1016/S0006-3495(02)75337-X. View

13.

Lew V, Hockaday A, Freeman C, Bookchin R . Mechanism of spontaneous inside-out vesiculation of red cell membranes. J Cell Biol. 1988; 106(6):1893-901. PMC: 2115135. DOI: 10.1083/jcb.106.6.1893. View

14.

Vriezema D, Garcia P, Sancho Oltra N, Hatzakis N, Kuiper S, Nolte R . Positional assembly of enzymes in polymersome nanoreactors for cascade reactions. Angew Chem Int Ed Engl. 2007; 46(39):7378-82. DOI: 10.1002/anie.200701125. View

15.

Napoli A, Valentini M, Tirelli N, Muller M, Hubbell J . Oxidation-responsive polymeric vesicles. Nat Mater. 2004; 3(3):183-9. DOI: 10.1038/nmat1081. View

16.

Levine D, Ghoroghchian P, Freudenberg J, Zhang G, Therien M, Greene M . Polymersomes: a new multi-functional tool for cancer diagnosis and therapy. Methods. 2008; 46(1):25-32. PMC: 2714227. DOI: 10.1016/j.ymeth.2008.05.006. View

17.

Liu F, Eisenberg A . Preparation and pH triggered inversion of vesicles from poly(acrylic acid)-block-polystyrene-block-poly(4-vinyl pyridine). J Am Chem Soc. 2003; 125(49):15059-64. DOI: 10.1021/ja038142r. View

18.

Discher D, Eisenberg A . Polymer vesicles. Science. 2002; 297(5583):967-73. DOI: 10.1126/science.1074972. View

19.

Yang J, Pinol R, Gubellini F, Levy D, Albouy P, Keller P . Formation of polymer vesicles by liquid crystal amphiphilic block copolymers. Langmuir. 2006; 22(18):7907-11. DOI: 10.1021/la061436g. View

20.

Du J, Tang Y, Lewis A, Armes S . pH-sensitive vesicles based on a biocompatible zwitterionic diblock copolymer. J Am Chem Soc. 2005; 127(51):17982-3. DOI: 10.1021/ja056514l. View