Alpha 2.0
Login Register
» Articles » PMID: 10485870

Dynamics of Transient Pores in Stretched Vesicles

Overview
Journal Proc Natl Acad Sci U S A
Specialty Science
Date 1999 Sep 15
PMID 10485870
Citations 93
Authors
O Sandre
L Moreaux
F Brochard-Wyart
Affiliations
Soon will be listed here.
Abstract

We image macroscopic transient pores in mechanically stretched giant vesicles. Holes open above a critical radius r(c1), grow up to a radius r(c2), and close. We interpret the upper limit r(c2) by a relaxation of the membrane tension as the holes expand. The closing of the holes is caused by a further relaxation of the surface tension when the internal liquid leaks out. A dynamic model fits our data for the growth and closure of pores.

Citing Articles

Interleaflet Translocation of Second-Harmonic-Generation-Active Dye Molecules in Phospholipid Bilayers with Transmembrane Pores.

Shigematsu T, Shinoda Y, Takagi R, Ujihara Y, Sugita S, Nakamura M Langmuir. 2025; 41(5):3209-3219.

PMID: 39875332 PMC: 11823627. DOI: 10.1021/acs.langmuir.4c03943.

Carboxy-Amidated AamAP1-Lys has Superior Conformational Flexibility and Accelerated Killing of Gram-Negative Bacteria.

Van Wyk R, Serem J, Oosthuizen C, Semenya D, Serian M, Lorenz C Biochemistry. 2025; 64(4):841-859.

PMID: 39873636 PMC: 11840929. DOI: 10.1021/acs.biochem.4c00580.

Fission of double-membrane tubes under tension.

Spencer R, Santos-Perez I, Shnyrova A, Muller M Biophys J. 2024; 123(22):3977-3996.

PMID: 39410713 PMC: 11617631. DOI: 10.1016/j.bpj.2024.10.009.

Curvature-Assisted Vesicle Explosion Under Light-Induced Asymmetric Oxidation.

Malik V, Pak O, Feng J Adv Sci (Weinh). 2024; 11(38):e2400504.

PMID: 39136143 PMC: 11481189. DOI: 10.1002/advs.202400504.

Vesicular neurotransmitters exocytosis monitored by amperometry: theoretical quantitative links between experimental current spikes shapes and intravesicular structures.

Dannaoui R, Hu R, Hu L, Tian Z, Svir I, Huang W Chem Sci. 2024; .

PMID: 39129778 PMC: 11310864. DOI: 10.1039/d4sc04003a.

References
1.
Remy J, Kichler A, Mordvinov V, Schuber F, Behr J . Targeted gene transfer into hepatoma cells with lipopolyamine-condensed DNA particles presenting galactose ligands: a stage toward artificial viruses. Proc Natl Acad Sci U S A. 1995; 92(5):1744-8. PMC: 42596. DOI: 10.1073/pnas.92.5.1744. View
2.
Saitoh A, Takiguchi K, Tanaka Y, Hotani H . Opening-up of liposomal membranes by talin. Proc Natl Acad Sci U S A. 1998; 95(3):1026-31. PMC: 18660. DOI: 10.1073/pnas.95.3.1026. View
3.
Ledley F . Nonviral gene therapy: the promise of genes as pharmaceutical products. Hum Gene Ther. 1995; 6(9):1129-44. DOI: 10.1089/hum.1995.6.9-1129. View
4.
Evans , Rawicz . Entropy-driven tension and bending elasticity in condensed-fluid membranes. Phys Rev Lett. 1990; 64(17):2094-2097. DOI: 10.1103/PhysRevLett.64.2094. View
5.
Milner , Safran . Dynamical fluctuations of droplet microemulsions and vesicles. Phys Rev A Gen Phys. 1987; 36(9):4371-4379. DOI: 10.1103/physreva.36.4371. View