Large-scale Genomic Analysis of Ovarian Carcinomas

Overview

Journal Mol Oncol

Specialties Molecular Biology
Oncology

Date 2009 Apr 23

PMID 19383377

Citations 17

Authors

Kylie L Gorringe

Ian G Campbell

Affiliations

Soon will be listed here.

Abstract

Epithelial ovarian cancers are typified by frequent genomic aberrations that have been difficult to unravel. Recently, high-resolution array technologies have provided the first glimpse of the remarkable complexity of these aberrations with some ovarian cancers containing hundreds of copy number breakpoints, micro-deletions and amplifications. Many of these alterations contain cancer-related genes suggesting that the majority is disease-associated and not just the product of random genomic instability. Future developments such as next-generation sequencing and integrated analysis of data from multiple array platforms on large numbers of samples are poised to revolutionize our understanding of this complex disease.

Citing Articles

Next-generation sequencing-based genomic profiling analysis reveals novel mutations for clinical diagnosis in Chinese primary epithelial ovarian cancer patients.

Zhang L, Luo M, Yang H, Zhu S, Cheng X, Qing C J Ovarian Res. 2019; 12(1):19.

PMID: 30786925 PMC: 6381667. DOI: 10.1186/s13048-019-0494-4.

Functional characterisation of a novel ovarian cancer cell line, NUOC-1.

McCormick A, Earp E, Elliot K, Cuthbert G, ODonnell R, Wilson B Oncotarget. 2017; 8(16):26832-26844.

PMID: 28460465 PMC: 5432300. DOI: 10.18632/oncotarget.15821.

Low levels of IGFBP7 expression in high-grade serous ovarian carcinoma is associated with patient outcome.

Gambaro K, Quinn M, Caceres-Gorriti K, Shapiro R, Provencher D, Rahimi K BMC Cancer. 2015; 15:135.

PMID: 25886299 PMC: 4381406. DOI: 10.1186/s12885-015-1138-8.

Deletion at 6q24.2-26 predicts longer survival of high-grade serous epithelial ovarian cancer patients.

Kamieniak M, Rico D, Milne R, Munoz-Repeto I, Ibanez K, Grillo M Mol Oncol. 2014; 9(2):422-36.

PMID: 25454820 PMC: 5528660. DOI: 10.1016/j.molonc.2014.09.010.

The pathogenesis of atypical proliferative Brenner tumor: an immunohistochemical and molecular genetic analysis.

Kuhn E, Ayhan A, Shih I, Seidman J, Kurman R Mod Pathol. 2013; 27(2):231-7.

PMID: 23887305 PMC: 4612641. DOI: 10.1038/modpathol.2013.142.

References

Bernardini M, Lee C, Beheshti B, Prasad M, Albert M, Marrano P . High-resolution mapping of genomic imbalance and identification of gene expression profiles associated with differential chemotherapy response in serous epithelial ovarian cancer. Neoplasia. 2005; 7(6):603-13. PMC: 1501280. DOI: 10.1593/neo.04760. View

Bignell G, Santarius T, Pole J, Butler A, Perry J, Pleasance E . Architectures of somatic genomic rearrangement in human cancer amplicons at sequence-level resolution. Genome Res. 2007; 17(9):1296-303. PMC: 1950898. DOI: 10.1101/gr.6522707. View

Jacobs S, Thompson E, Nannya Y, Yamamoto G, Pillai R, Ogawa S . Genome-wide, high-resolution detection of copy number, loss of heterozygosity, and genotypes from formalin-fixed, paraffin-embedded tumor tissue using microarrays. Cancer Res. 2007; 67(6):2544-51. DOI: 10.1158/0008-5472.CAN-06-3597. View

Haas C, Diebold J, Hirschmann A, Rohrbach H, Lohrs U . In serous ovarian neoplasms the frequency of Ki-ras mutations correlates with their malignant potential. Virchows Arch. 1999; 434(2):117-20. DOI: 10.1007/s004280050314. View

Kim S, Kim J, Kim Y, Kim J, Kim S, Yoon B . Analysis of chromosomal changes in serous ovarian carcinoma using high-resolution array comparative genomic hybridization: Potential predictive markers of chemoresistant disease. Genes Chromosomes Cancer. 2006; 46(1):1-9. DOI: 10.1002/gcc.20384. View

Feltmate C, Lee K, Johnson M, Schorge J, Wong K, Hao K . Whole-genome allelotyping identified distinct loss-of-heterozygosity patterns in mucinous ovarian and appendiceal carcinomas. Clin Cancer Res. 2005; 11(21):7651-7. DOI: 10.1158/1078-0432.CCR-05-1008. View

Sonoda G, Palazzo J, Du Manoir S, Godwin A, Feder M, Yakushiji M . Comparative genomic hybridization detects frequent overrepresentation of chromosomal material from 3q26, 8q24, and 20q13 in human ovarian carcinomas. Genes Chromosomes Cancer. 1997; 20(4):320-8. View

Ley T, Mardis E, Ding L, Fulton B, McLellan M, Chen K . DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome. Nature. 2008; 456(7218):66-72. PMC: 2603574. DOI: 10.1038/nature07485. View

Campbell P, Stephens P, Pleasance E, OMeara S, Li H, Santarius T . Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing. Nat Genet. 2008; 40(6):722-9. PMC: 2705838. DOI: 10.1038/ng.128. View

10.

Futreal P, Coin L, Marshall M, Down T, Hubbard T, Wooster R . A census of human cancer genes. Nat Rev Cancer. 2004; 4(3):177-83. PMC: 2665285. DOI: 10.1038/nrc1299. View

11.

Tomlinson I, Lambros M, Roylance R . Loss of heterozygosity analysis: practically and conceptually flawed?. Genes Chromosomes Cancer. 2002; 34(4):349-53. DOI: 10.1002/gcc.10085. View

12.

Hodges E, Xuan Z, Balija V, Kramer M, Molla M, Smith S . Genome-wide in situ exon capture for selective resequencing. Nat Genet. 2007; 39(12):1522-7. DOI: 10.1038/ng.2007.42. View

13.

Greshock J, Feng B, Nogueira C, Ivanova E, Perna I, Nathanson K . A comparison of DNA copy number profiling platforms. Cancer Res. 2007; 67(21):10173-80. DOI: 10.1158/0008-5472.CAN-07-2102. View

14.

Mitelman F, Mertens F, Johansson B . A breakpoint map of recurrent chromosomal rearrangements in human neoplasia. Nat Genet. 1997; 15 Spec No:417-74. DOI: 10.1038/ng0497supp-417. View

15.

Albert T, Molla M, Muzny D, Nazareth L, Wheeler D, Song X . Direct selection of human genomic loci by microarray hybridization. Nat Methods. 2007; 4(11):903-5. DOI: 10.1038/nmeth1111. View

16.

Ramus S, Pharoah P, Harrington P, Pye C, Werness B, Bobrow L . BRCA1/2 mutation status influences somatic genetic progression in inherited and sporadic epithelial ovarian cancer cases. Cancer Res. 2003; 63(2):417-23. View

17.

Forbes S, Clements J, Dawson E, Bamford S, Webb T, Dogan A . COSMIC 2005. Br J Cancer. 2006; 94(2):318-22. PMC: 2361125. DOI: 10.1038/sj.bjc.6602928. View

18.

Campbell I, Russell S, Choong D, Montgomery K, Ciavarella M, Hooi C . Mutation of the PIK3CA gene in ovarian and breast cancer. Cancer Res. 2004; 64(21):7678-81. DOI: 10.1158/0008-5472.CAN-04-2933. View

19.

Cavenee W, Dryja T, Phillips R, Benedict W, Godbout R, Gallie B . Expression of recessive alleles by chromosomal mechanisms in retinoblastoma. Nature. 1983; 305(5937):779-84. DOI: 10.1038/305779a0. View

20.

Lambros M, Fiegler H, Jones A, Gorman P, Roylance R, Carter N . Analysis of ovarian cancer cell lines using array-based comparative genomic hybridization. J Pathol. 2004; 205(1):29-40. DOI: 10.1002/path.1681. View