A Twist of Insight - the Role of Twist-family BHLH Factors in Development

Overview

Journal Int J Dev Biol

Specialties Biology
Reproductive Medicine

Date 2009 Apr 21

PMID 19378251

Citations 85

Authors

Ralston M Barnes

Anthony B Firulli

Affiliations

Soon will be listed here.

Abstract

Members of the Twist-family of bHLH proteins play a pivotal role in a number of essential developmental programs. Twist-family bHLH proteins function by dimerizing with other bHLH members and binding to cis- regulatory elements, called E-boxes. While Twist-family members may simply exhibit a preference in terms of high-affinity binding partners, a complex, multilevel cascade of regulation creates a dynamic role for these bHLH proteins. We summarize in this review information on each Twist-family member concerning expression pattern, function, regulation, downstream targets, and interactions with other bHLH proteins. Additionally, we focus on the phospho-regulatory mechanisms that tightly control posttranslational modification of Twist-family member bHLH proteins.

Citing Articles

The molecular mechanisms of cardiac development and related diseases.

Li Y, Du J, Deng S, Liu B, Jing X, Yan Y Signal Transduct Target Ther. 2024; 9(1):368.

PMID: 39715759 PMC: 11666744. DOI: 10.1038/s41392-024-02069-8.

PDGFRA is a conserved HAND2 effector during early cardiac development.

Xu Y, Gehlot R, Capon S, Albu M, Gretz J, Bloomekatz J Nat Cardiovasc Res. 2024; 3(12):1531-1548.

PMID: 39658721 PMC: 11634778. DOI: 10.1038/s44161-024-00574-1.

BPA Exposure Affects Mouse Gastruloids Axial Elongation by Perturbing the Wnt/β-Catenin Pathway.

Rebuzzini P, Rustichelli S, Fassina L, Canobbio I, Zuccotti M, Garagna S Int J Mol Sci. 2024; 25(14).

PMID: 39063166 PMC: 11276681. DOI: 10.3390/ijms25147924.

Integrative analysis of transcriptomic and epigenomic data reveals distinct patterns for developmental and housekeeping gene regulation.

Abnizova I, Stapel C, Boekhorst R, Lee J, Hemberg M BMC Biol. 2024; 22(1):78.

PMID: 38600550 PMC: 11005181. DOI: 10.1186/s12915-024-01869-2.

Role of STAT3 in cancer cell epithelial‑mesenchymal transition (Review).

Zhang G, Hou S, Li S, Wang Y, Cui W Int J Oncol. 2024; 64(5).

PMID: 38488027 PMC: 11000535. DOI: 10.3892/ijo.2024.5636.

References

Hill A, Riley P . Differential regulation of Hand1 homodimer and Hand1-E12 heterodimer activity by the cofactor FHL2. Mol Cell Biol. 2004; 24(22):9835-47. PMC: 525463. DOI: 10.1128/MCB.24.22.9835-9847.2004. View

Firulli A, McFADDEN D, Lin Q, Srivastava D, Olson E . Heart and extra-embryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand1. Nat Genet. 1998; 18(3):266-70. DOI: 10.1038/ng0398-266. View

McFadden D, Barbosa A, Richardson J, Schneider M, Srivastava D, Olson E . The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner. Development. 2004; 132(1):189-201. DOI: 10.1242/dev.01562. View

Aiyer A, Honarpour N, Herz J, Srivastava D . Loss of Apaf-1 leads to partial rescue of the HAND2-null phenotype. Dev Biol. 2005; 278(1):155-62. DOI: 10.1016/j.ydbio.2004.11.001. View

Ma L, Teruya-Feldstein J, Weinberg R . Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature. 2007; 449(7163):682-8. DOI: 10.1038/nature06174. View

Zeisberg E, Ma Q, Juraszek A, Moses K, Schwartz R, Izumo S . Morphogenesis of the right ventricle requires myocardial expression of Gata4. J Clin Invest. 2005; 115(6):1522-31. PMC: 1090473. DOI: 10.1172/JCI23769. View

Burgess R, Rawls A, Brown D, Bradley A, Olson E . Requirement of the paraxis gene for somite formation and musculoskeletal patterning. Nature. 1996; 384(6609):570-3. DOI: 10.1038/384570a0. View

DAutreaux F, Morikawa Y, Cserjesi P, Gershon M . Hand2 is necessary for terminal differentiation of enteric neurons from crest-derived precursors but not for their migration into the gut or for formation of glia. Development. 2007; 134(12):2237-49. DOI: 10.1242/dev.003814. View

Dai Y, Cserjesi P, Markham B, Molkentin J . The transcription factors GATA4 and dHAND physically interact to synergistically activate cardiac gene expression through a p300-dependent mechanism. J Biol Chem. 2002; 277(27):24390-8. DOI: 10.1074/jbc.M202490200. View

10.

Riley P, Gertsenstein M, Dawson K, CROSS J . Early exclusion of hand1-deficient cells from distinct regions of the left ventricular myocardium in chimeric mouse embryos. Dev Biol. 2000; 227(1):156-68. DOI: 10.1006/dbio.2000.9864. View

11.

Perrin-Schmitt F, Bolcato-Bellemin A, Bourgeois P, Stoetzel C, Danse J . The locations of the H-twist and H-dermo-1 genes are distinct on the human genome. Biochim Biophys Acta. 1997; 1360(1):1-2. DOI: 10.1016/s0925-4439(96)00071-3. View

12.

Risebro C, Smart N, Dupays L, Breckenridge R, Mohun T, Riley P . Hand1 regulates cardiomyocyte proliferation versus differentiation in the developing heart. Development. 2006; 133(22):4595-606. DOI: 10.1242/dev.02625. View

13.

Howard M, Stanke M, Schneider C, Wu X, Rohrer H . The transcription factor dHAND is a downstream effector of BMPs in sympathetic neuron specification. Development. 2000; 127(18):4073-81. DOI: 10.1242/dev.127.18.4073. View

14.

Giebel B, Stuttem I, Hinz U, Campos-Ortega J . Lethal of scute requires overexpression of daughterless to elicit ectopic neuronal development during embryogenesis in Drosophila. Mech Dev. 1997; 63(1):75-87. DOI: 10.1016/s0925-4773(97)00029-4. View

15.

Zuniga A, Zeller R . Gli3 (Xt) and formin (ld) participate in the positioning of the polarising region and control of posterior limb-bud identity. Development. 1998; 126(1):13-21. DOI: 10.1242/dev.126.1.13. View

16.

Vincentz J, Barnes R, Rodgers R, Firulli B, Conway S, Firulli A . An absence of Twist1 results in aberrant cardiac neural crest morphogenesis. Dev Biol. 2008; 320(1):131-9. PMC: 2572997. DOI: 10.1016/j.ydbio.2008.04.037. View

17.

Locascio A, Nieto M . Cell movements during vertebrate development: integrated tissue behaviour versus individual cell migration. Curr Opin Genet Dev. 2001; 11(4):464-9. DOI: 10.1016/s0959-437x(00)00218-5. View

18.

Rychlik J, Gerbasi V, Lewis E . The interaction between dHAND and Arix at the dopamine beta-hydroxylase promoter region is independent of direct dHAND binding to DNA. J Biol Chem. 2003; 278(49):49652-60. DOI: 10.1074/jbc.M308577200. View

19.

Dai Y, Hao J, Bonin C, Morikawa Y, Cserjesi P . JAB1 enhances HAND2 transcriptional activity by regulating HAND2 DNA binding. J Neurosci Res. 2004; 76(5):613-22. DOI: 10.1002/jnr.20105. View

20.

Seto M, Hing A, Chang J, Hu M, Kapp-Simon K, Patel P . Isolated sagittal and coronal craniosynostosis associated with TWIST box mutations. Am J Med Genet A. 2007; 143A(7):678-86. DOI: 10.1002/ajmg.a.31630. View