Role of STAT3 in Cancer Cell Epithelial‑mesenchymal Transition (Review)

Overview

Journal Int J Oncol

Specialty Oncology

Date 2024 Mar 15

PMID 38488027

Authors

Guoan Zhang

Sen Hou

Shuyue Li

Yequan Wang

Wen Cui

Affiliations

Soon will be listed here.

Abstract

Since its discovery, the role of the transcription factor, signal transducer and activator of transcription 3 (STAT3), in both normal physiology and the pathology of numerous diseases, including cancer, has been extensively studied. STAT3 is aberrantly activated in different types of cancer, fulfilling a critical role in cancer progression. The biological process, epithelial‑mesenchymal transition (EMT), is indispensable for embryonic morphogenesis. During the development of cancer, EMT is hijacked to confer motility, tumor cell stemness, drug resistance and adaptation to changes in the microenvironment. The aim of the present review was to outline recent advances in knowledge of the role of STAT3 in EMT, which may contribute to the understanding of the function of STAT3 in EMT in various types of cancer. Delineating the underlying mechanisms associated with the STAT3‑EMT signaling axis may generate novel diagnostic and therapeutic options for cancer treatment.

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