Dynamic Patterning Programmed by DNA Tiles Captured on a DNA Origami Substrate

Overview

Journal Nat Nanotechnol

Specialty Biotechnology

Date 2009 Apr 8

PMID 19350035

Citations 26

Authors

Hongzhou Gu

Jie Chao

Shou-Jun Xiao

Nadrian C Seeman

Affiliations

Soon will be listed here.

Abstract

The aim of nanotechnology is to put specific atomic and molecular species where we want them, when we want them there. Achieving such dynamic and functional control could lead to programmable chemical synthesis and nanoscale systems that are responsive to their environments. Structural DNA nanotechnology offers a powerful route to this goal by combining stable branched DNA motifs with cohesive ends to produce programmed nanomechanical devices and fixed or modified patterned lattices. Here, we demonstrate a dynamic form of patterning in which a pattern component is captured between two independently programmed DNA devices. A simple and robust error-correction protocol has been developed that yields programmed targets in all cases. This capture system can lead to dynamic control either on patterns or on programmed elements; this capability enables computation or a change of structural state as a function of information in the surroundings of the system.

Citing Articles

Nucleic acid nanostructures for applications: The influence of morphology on biological fate.

Langlois N, Ma K, Clark H Appl Phys Rev. 2023; 10(1):011304.

PMID: 36874908 PMC: 9869343. DOI: 10.1063/5.0121820.

Nanopore fingerprinting of supramolecular DNA nanostructures.

Confederat S, Sandei I, Mohanan G, Walti C, Actis P Biophys J. 2022; 121(24):4882-4891.

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Design Approaches and Computational Tools for DNA Nanostructures.

Koh H, Lee J, Lee J, Kim R, Tabata O, Jin-Woo K IEEE Open J Nanotechnol. 2022; 2:86-100.

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Complex between a Multicrossover DNA Nanostructure, PX-DNA, and T7 Endonuclease I.

Kizer M, Huntress I, Walcott B, Fraser K, Bystroff C, Wang X Biochemistry. 2019; 58(10):1332-1342.

PMID: 30794750 PMC: 7375024. DOI: 10.1021/acs.biochem.9b00057.

DNA Origami Nanomachines.

Endo M, Sugiyama H Molecules. 2018; 23(7).

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