Functional DNAzymes Organized into Two-dimensional Arrays

Overview

Journal Nano Lett

Publisher American Chemical Society

Specialty Biotechnology

Date 2006 Jul 13

PMID 16834439

Citations 11

Authors

Alejandra V Garibotti

Scott M Knudsen

Andrew D Ellington

Nadrian C Seeman

Affiliations

Soon will be listed here.

Abstract

DNAzymes are catalytically active DNA molecules, which have previously been described in solution. Here, we organize these molecules into a series of two-dimensional (2D) arrays using a periodic arrangement of DNA structures based on the DNA double crossover motif. We demonstrate by means of atomic force microscopy that the DNAzymes are organized according to the design and that they retain their activity when attached in linear strings within the context of the 2D array.

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