Novel Antigens in Type 1 Diabetes: the Importance of ZnT8

Overview

Journal Curr Diab Rep

Publisher Current Science

Specialty Endocrinology

Date 2009 Mar 28

PMID 19323954

Citations 25

Authors

Janet M Wenzlau

Lisa M Frisch

Thomas J Gardner

Suparna Sarkar

John C Hutton

Howard W Davidson

Affiliations

Soon will be listed here.

Abstract

The presence of circulating islet cell autoantibodies distinguishes type 1A diabetes (T1D) from other diabetic syndromes and determination of autoantigen genes and proteins is instrumental in understanding T1D as a clinical entity and in investigating the pathogenesis of the disease. ZnT8 was recently defined as a candidate autoantigen based on a -bioinformatics analysis focused on discovery of beta-cell-specific proteins associated with the regulatory pathway of secretion. The native molecule does not lend itself easily to solution-phase autoantibody assays, but ligands based on the predicted domain structure and molecular modeling have led to robust diagnostic procedures showing high specificities and sensitivities that complement current T1D autoantibody assays and add to the predictive value of their measurement. The incorporation of genetic and structural epitope analysis into ZnT8A determinations adds a further dimension to its diagnostic value and understanding of its role in the autoimmune disease process.

Citing Articles

ZnT8 Exerts Anti-apoptosis of Kidney Tubular Epithelial Cell in Diabetic Kidney Disease Through TNFAIP3-NF-κB Signal Pathways.

Chi Y, Zhang X, Liang D, Wang Y, Cai X, Dong J Biol Trace Elem Res. 2022; 201(5):2442-2457.

PMID: 35871203 DOI: 10.1007/s12011-022-03361-w.

Autoantibodies to Zinc Transporter 8 and Genotype in Type 1 Diabetes Childhood: A Pioneering Study in North Africa.

Fakhfakh R, Kmiha S, Tahri S, Feki S, Zouidi F, Abida O J Diabetes Res. 2022; 2022:2539871.

PMID: 35656360 PMC: 9152414. DOI: 10.1155/2022/2539871.

The Role of Heat Shock Proteins in Type 1 Diabetes.

Moin A, Nandakumar M, Diane A, Dehbi M, Butler A Front Immunol. 2021; 11:612584.

PMID: 33584694 PMC: 7873876. DOI: 10.3389/fimmu.2020.612584.

Zinc transporter 8 autoantibody in the diagnosis of type 1 diabetes in children.

Rochmah N, Faizi M, Windarti S Clin Exp Pediatr. 2020; 63(10):402-405.

PMID: 33050689 PMC: 7568951. DOI: 10.3345/cep.2019.01221.

Effects of ZnT8 on epithelial-to-mesenchymal transition and tubulointerstitial fibrosis in diabetic kidney disease.

Zhang X, Guan T, Yang B, Gu H, Chi Z Cell Death Dis. 2020; 11(7):544.

PMID: 32681069 PMC: 7367835. DOI: 10.1038/s41419-020-2731-6.

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