Zinc is a Novel Intracellular Second Messenger

Overview

Journal J Cell Biol

Specialty Cell Biology

Date 2007 May 16

PMID 17502426

Citations 243

Authors

Satoru Yamasaki

Kumiko Sakata-Sogawa

Aiko Hasegawa

Tomoyuki Suzuki

Koki Kabu

Emi Sato

Tomohiro Kurosaki

Susumu Yamashita

Makio Tokunaga

Keigo Nishida

Toshio Hirano

Affiliations

Soon will be listed here.

Abstract

Zinc is an essential trace element required for enzymatic activity and for maintaining the conformation of many transcription factors; thus, zinc homeostasis is tightly regulated. Although zinc affects several signaling molecules and may act as a neurotransmitter, it remains unknown whether zinc acts as an intracellular second messenger capable of transducing extracellular stimuli into intracellular signaling events. In this study, we report that the cross-linking of the high affinity immunoglobin E receptor (Fcepsilon receptor I [FcepsilonRI]) induced a release of free zinc from the perinuclear area, including the endoplasmic reticulum in mast cells, a phenomenon we call the zinc wave. The zinc wave was dependent on calcium influx and mitogen-activated protein kinase/extracellular signal-regulated kinase kinase activation. The results suggest that the zinc wave is involved in intracellular signaling events, at least in part by modulating the duration and strength of FcepsilonRI-mediated signaling. Collectively, our findings indicate that zinc is a novel intracellular second messenger.

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