Light-activation of Gene Function in Mammalian Cells Via Ribozymes

Overview

Journal Chem Commun (Camb)

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2009 Mar 14

PMID 19283293

Citations 15

Authors

Douglas D Young

R Aaron Garner

Jeffrey A Yoder

Alexander Deiters

Affiliations

Soon will be listed here.

Abstract

A ribozyme based gene control element enabled the spatio-temporal regulation of gene function in mammalian cell culture with light.

Citing Articles

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Controlling gene expression with light: a multidisciplinary endeavour.

Hartmann D, Smith J, Mazzotti G, Chowdhry R, Booth M Biochem Soc Trans. 2020; 48(4):1645-1659.

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Regulation of mRNA translation by a photoriboswitch.

Rotstan K, Abdelsayed M, Passalacqua L, Chizzolini F, Sudarshan K, Chamberlin A Elife. 2020; 9.

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References

Winkler W, Breaker R . Genetic control by metabolite-binding riboswitches. Chembiochem. 2003; 4(10):1024-32. DOI: 10.1002/cbic.200300685. View

Cambridge S, Geissler D, Keller S, Curten B . A caged doxycycline analogue for photoactivated gene expression. Angew Chem Int Ed Engl. 2006; 45(14):2229-31. DOI: 10.1002/anie.200503339. View

Mandal M, Breaker R . Gene regulation by riboswitches. Nat Rev Mol Cell Biol. 2004; 5(6):451-63. DOI: 10.1038/nrm1403. View

Tucker B, Breaker R . Riboswitches as versatile gene control elements. Curr Opin Struct Biol. 2005; 15(3):342-8. DOI: 10.1016/j.sbi.2005.05.003. View

Tang X, Dmochowski I . Regulating gene expression with light-activated oligonucleotides. Mol Biosyst. 2007; 3(2):100-10. DOI: 10.1039/b614349k. View

Breaker R . Natural and engineered nucleic acids as tools to explore biology. Nature. 2004; 432(7019):838-45. DOI: 10.1038/nature03195. View

Kawasaki H, Wadhwa R, Taira K . World of small RNAs: from ribozymes to siRNA and miRNA. Differentiation. 2004; 72(2-3):58-64. DOI: 10.1111/j.1432-0436.2004.07202006.x. View

Yousefi-Salakdeh E, Murtola M, Zetterberg A, Yeheskiely E, Stromberg R . Synthesis of 8-aminoadenosine 5'-(aminoalkyl phosphates), analogues of aminoacyl adenylates. Bioorg Med Chem. 2005; 14(8):2653-9. DOI: 10.1016/j.bmc.2005.11.049. View

Rossi J . Controlled, targeted, intracellular expression of ribozymes: progress and problems. Trends Biotechnol. 1995; 13(8):301-6. DOI: 10.1016/S0167-7799(00)88969-6. View

10.

Blount K, Uhlenbeck O . The hammerhead ribozyme. Biochem Soc Trans. 2002; 30(Pt 6):1119-22. DOI: 10.1042/bst0301119. View

11.

Win M, Smolke C . RNA as a versatile and powerful platform for engineering genetic regulatory tools. Biotechnol Genet Eng Rev. 2007; 24:311-46. DOI: 10.1080/02648725.2007.10648106. View

12.

Brantl S . Bacterial gene regulation: from transcription attenuation to riboswitches and ribozymes. Trends Microbiol. 2004; 12(11):473-5. DOI: 10.1016/j.tim.2004.09.008. View

13.

Winkler W, Nahvi A, Roth A, Collins J, Breaker R . Control of gene expression by a natural metabolite-responsive ribozyme. Nature. 2004; 428(6980):281-6. DOI: 10.1038/nature02362. View

14.

Mayer G, Heckel A . Biologically active molecules with a "light switch". Angew Chem Int Ed Engl. 2006; 45(30):4900-21. DOI: 10.1002/anie.200600387. View

15.

Khan A, Lal S . Ribozymes: a modern tool in medicine. J Biomed Sci. 2003; 10(5):457-67. DOI: 10.1007/BF02256107. View

16.

Strobel S, Cochrane J . RNA catalysis: ribozymes, ribosomes, and riboswitches. Curr Opin Chem Biol. 2007; 11(6):636-43. PMC: 2184879. DOI: 10.1016/j.cbpa.2007.09.010. View

17.

Lin W, Lawrence D . A strategy for the construction of caged diols using a photolabile protecting group. J Org Chem. 2002; 67(8):2723-6. DOI: 10.1021/jo0163851. View

18.

Yen L, Magnier M, Weissleder R, Stockwell B, Mulligan R . Identification of inhibitors of ribozyme self-cleavage in mammalian cells via high-throughput screening of chemical libraries. RNA. 2006; 12(5):797-806. PMC: 1440893. DOI: 10.1261/rna.2300406. View

19.

Robert C, MUEL B, Benoit A, Dubertret L, Sarasin A, Stary A . Cell survival and shuttle vector mutagenesis induced by ultraviolet A and ultraviolet B radiation in a human cell line. J Invest Dermatol. 1996; 106(4):721-8. DOI: 10.1111/1523-1747.ep12345616. View

20.

Schindl A, Klosner G, Honigsmann H, Jori G, Trautinger F . Flow cytometric quantification of UV-induced cell death in a human squamous cell carcinoma-derived cell line: dose and kinetic studies. J Photochem Photobiol B. 1998; 44(2):97-106. DOI: 10.1016/s1011-1344(98)00127-4. View