Parenteral Nutrition Maintains Pulmonary IgA Antibody Transport Capacity, but Not Active Transport, Following Injury

Overview

Journal Am J Surg

Specialty General Surgery

Date 2009 Mar 3

PMID 19249732

Citations 14

Authors

Yoshifumi Sano

Joshua L Hermsen

Woodae Kang

F Enrique Gomez

Jinggang Lan

Yoshinori Maeshima

Kenneth A Kudsk

Affiliations

Soon will be listed here.

Abstract

Background: Parenteral nutrition (PN) increases post-trauma pneumonia versus enteral feeding. PN impairs murine immunoglobulin A (IgA) airway defenses and abrogates a normal IgA increase following injury. This work investigates the effect of type/route of nutrition on lung IgA and its transport protein, polymeric immunoglobulin receptor (pIgR), after injury.

Methods: Catheterized mice were randomized to Chow or PN for 5 days and sacrificed without injury (Chow: n = 12; PN n = 11), or 8 hours after laparotomy + neck incisions (Chow-injury: n = 11, PN-injury: n = 13). Bronchoalveolar lavage (BAL) and lung IgA levels were analyzed by enzyme-linked immunosorbent assay (ELISA) and lung pIgR by Western blot.

Results: BAL IgA levels increased in Chow-injury versus PN-injury (P <.01) with no differences in pIgR. PN-injury tissue IgA levels decreased versus Chow (P <.01), Chow-injury (P <.01), and PN (P <.05).

Conclusions: PN impairs the airway IgA response to injury but not due to impaired IgA transport capacity/pIgR level.

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References

Kudsk K, Hermsen J, Genton L, Faucher L, Gomez F . Injury stimulates an innate respiratory immunoglobulin a immune response in humans. J Trauma. 2008; 64(2):316-23. DOI: 10.1097/TA.0b013e3181627586. View

Schjerven H, Brandtzaeg P, Johansen F . A novel NF-kappa B/Rel site in intron 1 cooperates with proximal promoter elements to mediate TNF-alpha-induced transcription of the human polymeric Ig receptor. J Immunol. 2001; 167(11):6412-20. DOI: 10.4049/jimmunol.167.11.6412. View

Kudsk K . Effect of route and type of nutrition on intestine-derived inflammatory responses. Am J Surg. 2003; 185(1):16-21. DOI: 10.1016/s0002-9610(02)01146-7. View

Asahi Y, Yoshikawa T, Watanabe I, Iwasaki T, Hasegawa H, Sato Y . Protection against influenza virus infection in polymeric Ig receptor knockout mice immunized intranasally with adjuvant-combined vaccines. J Immunol. 2002; 168(6):2930-8. DOI: 10.4049/jimmunol.168.6.2930. View

Kudsk K, Croce M, Fabian T, Minard G, Tolley E, Poret H . Enteral versus parenteral feeding. Effects on septic morbidity after blunt and penetrating abdominal trauma. Ann Surg. 1992; 215(5):503-11; discussion 511-3. PMC: 1242485. DOI: 10.1097/00000658-199205000-00013. View

Sano Y, Gomez F, Hermsen J, Kang W, Lan J, Maeshima Y . Parenteral nutrition induces organ specific alterations in polymeric immunoglobulin receptor levels. J Surg Res. 2008; 149(2):236-42. PMC: 2561964. DOI: 10.1016/j.jss.2007.12.790. View

Renegar K, Jackson G, Mestecky J . In vitro comparison of the biologic activities of monoclonal monomeric IgA, polymeric IgA, and secretory IgA. J Immunol. 1998; 160(3):1219-23. View

Shimada S, Kushiro A, Sato T, Nanno M, Sako T, Matsuoka Y . Generation of polymeric immunoglobulin receptor-deficient mouse with marked reduction of secretory IgA. J Immunol. 1999; 163(10):5367-73. View

Fukatsu K, Zarzaur B, Johnson C, Lundberg A, WILCOX H, Kudsk K . Enteral nutrition prevents remote organ injury and death after a gut ischemic insult. Ann Surg. 2001; 233(5):660-8. PMC: 1421306. DOI: 10.1097/00000658-200105000-00010. View

10.

Fukatsu K, Lundberg A, Hanna M, Wu Y, WILCOX H, Granger D . Route of nutrition influences intercellular adhesion molecule-1 expression and neutrophil accumulation in intestine. Arch Surg. 1999; 134(10):1055-60. DOI: 10.1001/archsurg.134.10.1055. View

11.

Kaetzel C . The polymeric immunoglobulin receptor: bridging innate and adaptive immune responses at mucosal surfaces. Immunol Rev. 2005; 206:83-99. DOI: 10.1111/j.0105-2896.2005.00278.x. View

12.

Takagi K, Yamamori H, Toyoda Y, Nakajima N, Tashiro T . Modulating effects of the feeding route on stress response and endotoxin translocation in severely stressed patients receiving thoracic esophagectomy. Nutrition. 2000; 16(5):355-60. DOI: 10.1016/s0899-9007(00)00231-8. View

13.

Sitren H, Heller P, Bailey L, Cerda J . Total parenteral nutrition in the mouse: development of a technique. JPEN J Parenter Enteral Nutr. 1983; 7(6):582-6. DOI: 10.1177/0148607183007006582. View

14.

King B, Kudsk K, Li J, Wu Y, Renegar K . Route and type of nutrition influence mucosal immunity to bacterial pneumonia. Ann Surg. 1999; 229(2):272-8. PMC: 1191641. DOI: 10.1097/00000658-199902000-00016. View

15.

Moore F, Feliciano D, Andrassy R, McARDLE A, Booth F, Kellum Jr J . Early enteral feeding, compared with parenteral, reduces postoperative septic complications. The results of a meta-analysis. Ann Surg. 1992; 216(2):172-83. PMC: 1242589. DOI: 10.1097/00000658-199208000-00008. View

16.

Wu Y, Kudsk K, DeWitt R, Tolley E, Li J . Route and type of nutrition influence IgA-mediating intestinal cytokines. Ann Surg. 1999; 229(5):662-7; discussion 667-8. PMC: 1420810. DOI: 10.1097/00000658-199905000-00008. View

17.

Moore E, Moore F, Franciose R, Kim F, Biffl W, Banerjee A . The postischemic gut serves as a priming bed for circulating neutrophils that provoke multiple organ failure. J Trauma. 1994; 37(6):881-7. DOI: 10.1097/00005373-199412000-00002. View

18.

Moore E, Jones T . Benefits of immediate jejunostomy feeding after major abdominal trauma--a prospective, randomized study. J Trauma. 1986; 26(10):874-81. DOI: 10.1097/00005373-198610000-00003. View

19.

de Oliveira I, de Araujo A, Bao S, Giugliano L . Binding of lactoferrin and free secretory component to enterotoxigenic Escherichia coli. FEMS Microbiol Lett. 2001; 203(1):29-33. DOI: 10.1111/j.1574-6968.2001.tb10816.x. View

20.

Mostov K, Friedlander M, Blobel G . The receptor for transepithelial transport of IgA and IgM contains multiple immunoglobulin-like domains. Nature. 1984; 308(5954):37-43. DOI: 10.1038/308037a0. View