Morphological Equivalent of the Bifunctional Role of Somatostatin

Overview

Journal Cell Tissue Res

Specialties Anatomy & Histology
Cell Biology

Date 1977 Apr 7

PMID 192473

Citations 13

Authors

B Krisch

Affiliations

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Abstract

Using the immunoenzyme bridge-technique at the light and electron microscopic levels, somatostatin can be demonstrated in the perikarya of the anterior periventricular nucleus, in the median eminence and in the parvocellular hypothalamic nuclei of the rat. In the latter regions the perikarya are negative, whereas a positive reaction for somatostatin is found in a delicate network of fibers and middle-sized granules of very small axons. In light of these results, the double function of somatostatin-as release inhibiting hormone and as transmitter-is discussed. The positive staining reaction in the organum vasculosum laminae terminalis of male and female rats as well as in the subfornical organ, the nucleus dorsalis thalami and the nucleus medialis habenulae in female controls and pregnant rats is not due to somatostatin-containing structures, but partly to substance P and partlly to a substance which could not be defined.

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References

Dubois M . Immunoreactive somatostatin is present in discrete cells of the endocrine pancreas. Proc Natl Acad Sci U S A. 1975; 72(4):1340-3. PMC: 432529. DOI: 10.1073/pnas.72.4.1340. View

Straus W . Inhibition of peroxidase by methanol and by methanol-nitroferricyanide for use in immunoperoxidase procedures. J Histochem Cytochem. 1971; 19(11):682-8. DOI: 10.1177/19.11.682. View

VANDESANDE F, Dierickx K . Identification of the vasopressin producing and of the oxytocin producing neurons in the hypothalamic magnocellular neurosecretroy system of the rat. Cell Tissue Res. 1975; 164(2):153-62. DOI: 10.1007/BF00218970. View

Goldsmith P, Rose J, Arimura A, Ganong W . Ultrastructural localization of somatostatin in pancreatic islets of the rat. Endocrinology. 1975; 97(4):1061-4. DOI: 10.1210/endo-97-4-1061. View

SETALO G, Vigh S, Schally A, Arimura A, Flerko B . GH-RIH-containing neural elements in the rat hypothalamus. Brain Res. 1975; 90(2):352-6. DOI: 10.1016/0006-8993(75)90319-4. View

Brownstein M, Arimura A, Sato H, Schally A, Kizer J . The regional distribution of somatostatin in the rat brain. Endocrinology. 1975; 96(6):1456-61. DOI: 10.1210/endo-96-6-1456. View

Palkovits M, Brownstein M, Arimura A, Sato H, Schally V, Kizer J . Somatostatin content of the hypothalamic ventromedial and arcuate nuclei and the circumventricular organs in the rat. Brain Res. 1976; 109(2):430-4. DOI: 10.1016/0006-8993(76)90549-7. View

Efendic S, Luft R, Grill V . Effect of somatostatin on glucose induced insulin release in isolated perfused rat pancreas and isolated rat pancreatic islets. FEBS Lett. 1974; 42(2):169-72. DOI: 10.1016/0014-5793(74)80778-7. View

Kizer J, Palkovits M, Tappaz M, Kebabian J, Brownstein M . Distribution of releasing factors, biogenic amines, and related enzymes in the bovine median eminence. Endocrinology. 1976; 98(3):685-95. DOI: 10.1210/endo-98-3-685. View

10.

Dube D, LECLERC R, Pelletier G, Arimura Aschally A . Immunohistochemical detection of growth hormone-release inhibiting hormone (somatostatin) in the guinea-pig brain. Cell Tissue Res. 1975; 161(3):385-92. DOI: 10.1007/BF00220006. View

11.

Pelletier G, LECLERC R, Dube D, Labrie F, Puviani R, Arimura A . Localization of growth hormone-release-inhibiting hormone (somatostatin) in the rat brain. Am J Anat. 1975; 142(3):397-401. DOI: 10.1002/aja.1001420309. View

12.

Kizer J, Palkovits M, Brownstein M . Releasing factors in the circumventricular organs in the rat brain. Endocrinology. 1976; 98(2):311-7. DOI: 10.1210/endo-98-2-311. View

13.

Naik D . Immuno-histochemical localization of LH-RH during different phases of estrus cycle of rat, with reference to the preoptic and arcuate neurons, and the ependymal cells. Cell Tissue Res. 1976; 173(2):143-66. DOI: 10.1007/BF00221371. View

14.

Alpert L, Brawer J, Patel Y, Reichlin S . Somatostatinergic neurons in anterior hypothalamus: immunohistochemical localization. Endocrinology. 1976; 98(1):255-8. DOI: 10.1210/endo-98-1-255. View

15.

Hokfelt T, Efendic S, HELLERSTROM C, Johansson O, Luft R, Arimura A . Cellular localization of somatostatin in endocrine-like cells and neurons of the rat with special references to the A1-cells of the pancreatic islets and to the hypothalamus. Acta Endocrinol Suppl (Copenh). 1975; 200:5-41. View

16.

Elde R, Parsons J . Immunocytochemical localization of somatostatin in cell bodies of the rat hypothalamus. Am J Anat. 1975; 144(4):541-8. DOI: 10.1002/aja.1001440416. View

17.

Krisch B . Immunohistochemical and electron microscopic study of the rat hypothalamic nuclei and cell clusters under various experimental conditions. Possible sites of hormone release. Cell Tissue Res. 1976; 174(1):109-27. DOI: 10.1007/BF00222154. View

18.

Parsons J, Erlandsen S, Hegre O, McEvoy R, Elde R . Central and peripheral localization of somatostatin. Immunoenzyme immunocytochemical studies. J Histochem Cytochem. 1976; 24(7):872-82. DOI: 10.1177/24.7.60436. View

19.

Hokfelt T, Efendic S, Johansson O, Luft R, Arimura A . Immunohistochemical localization of somatostatin (growth hormone release-inhibiting factor) in the guinea pig brain. Brain Res. 1974; 80(1):165-9. DOI: 10.1016/0006-8993(74)90737-9. View

20.

Pelletier G, LECLERC R, Dube D . Immunohistochemical localization of hypothalamic hormones. J Histochem Cytochem. 1976; 24(7):864-71. DOI: 10.1177/24.7.784871. View