The Regional Distribution of Somatostatin in the Rat Brain

Overview

Journal Endocrinology

Publisher Oxford University Press

Specialty Endocrinology

Date 1975 Jun 1

PMID 1126315

Citations 58

Authors

M Brownstein

A Arimura

H Sato

A V Schally

J S Kizer

Affiliations

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Abstract

A sensitive and specific radioimmunoassay for somatostatin (SRIF) has been used to determine the regional distribution of SRIF in rat brain. The hypothalamus contained the highest concentration of SRIF. Lower, but significant amounts of SRIF were present outside of the hypothalalmus. Within the hypothalamus, the concentration of SRIF was highest in the median eminence and arcuate nucleus although all of the hypothalmic nuclei contained some fo this material. The implications of this distribution are discussed.

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