Telomeres Do the (un)twist: Helicase Actions at Chromosome Termini

Overview

Journal Biochim Biophys Acta

Specialties Biochemistry
Biophysics

Date 2009 Feb 28

PMID 19245831

Citations 11

Authors

Alejandro Chavez

Amy M Tsou

F Brad Johnson

Affiliations

Soon will be listed here.

Abstract

Telomeres play critical roles in protecting genome stability, and their dysfunction contributes to cancer and age-related degenerative diseases. The precise architecture of telomeres, including their single-stranded 3' overhangs, bound proteins, and ability to form unusual secondary structures such as t-loops, is central to their function and thus requires careful processing by diverse factors. Furthermore, telomeres provide unique challenges to the DNA replication and recombination machinery, and are particularly suited for extension by the telomerase reverse transcriptase. Helicases use the energy from NTP hydrolysis to track along DNA and disrupt base pairing. Here we review current findings concerning how helicases modulate several aspects of telomere form and function.

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