HDL, Lipid Peroxidation, and Atherosclerosis

Overview

Journal J Lipid Res

Publisher Elsevier

Specialty Biochemistry

Date 2009 Jan 15

PMID 19141435

Citations 45

Authors

Baohai Shao

Jay W Heinecke

Affiliations

Soon will be listed here.

Citing Articles

The Effects of Hydrogen-Rich Water on Blood Lipid Profiles in Metabolic Disorders Clinical Trials: A Systematic Review and Meta-analysis.

Jamialahmadi H, Khalili-Tanha G, Rezaei-Tavirani M, Nazari E Int J Endocrinol Metab. 2025; 22(3):e148600.

PMID: 39839806 PMC: 11742746. DOI: 10.5812/ijem-148600.

Protective Role of High-Density Lipoprotein in Multiple Sclerosis.

Damiza-Detmer A, Pawelczyk M, Glabinski A Antioxidants (Basel). 2024; 13(11).

PMID: 39594418 PMC: 11591269. DOI: 10.3390/antiox13111276.

L. Seed Oil Modulates Dyslipidemia and Neuronal Dysfunction in Tramadol-Induced Toxicity in Wistar Albino Rats.

Ekpono E, Aja P, Ibiam U, Agu P, Eze E, Afodun A Dose Response. 2024; 22(4):15593258241290458.

PMID: 39381131 PMC: 11457233. DOI: 10.1177/15593258241290458.

Lipid Oxidation Products and the Risk of Cardiovascular Diseases: Role of Lipoprotein Transport.

Ahotupa M Antioxidants (Basel). 2024; 13(5).

PMID: 38790617 PMC: 11117553. DOI: 10.3390/antiox13050512.

Isoform-specific modification of apolipoprotein E by 4-hydroxynonenal: protective role of apolipoprotein E3 against oxidative species.

Abeer M, Abdulhasan A, Haguar Z, Narayanaswami V FEBS J. 2023; 290(11):3006-3025.

PMID: 36661393 PMC: 11296219. DOI: 10.1111/febs.16729.

References

Heinecke J . Oxidants and antioxidants in the pathogenesis of atherosclerosis: implications for the oxidized low density lipoprotein hypothesis. Atherosclerosis. 1998; 141(1):1-15. DOI: 10.1016/s0021-9150(98)00173-7. View

Rader D, Pure E . Lipoproteins, macrophage function, and atherosclerosis: beyond the foam cell?. Cell Metab. 2005; 1(4):223-30. DOI: 10.1016/j.cmet.2005.03.005. View

Macphee C, Nelson J, Zalewski A . Lipoprotein-associated phospholipase A2 as a target of therapy. Curr Opin Lipidol. 2005; 16(4):442-6. DOI: 10.1097/01.mol.0000174155.61307.5f. View

Moore K, Roberts 2nd L . Measurement of lipid peroxidation. Free Radic Res. 1998; 28(6):659-71. DOI: 10.3109/10715769809065821. View

Witztum J, Steinberg D . Role of oxidized low density lipoprotein in atherogenesis. J Clin Invest. 1991; 88(6):1785-92. PMC: 295745. DOI: 10.1172/JCI115499. View

Savenkova M, Mueller D, Heinecke J . Tyrosyl radical generated by myeloperoxidase is a physiological catalyst for the initiation of lipid peroxidation in low density lipoprotein. J Biol Chem. 1994; 269(32):20394-400. View

Moore R, Navab M, Millar J, Zimetti F, Hama S, Rothblat G . Increased atherosclerosis in mice lacking apolipoprotein A-I attributable to both impaired reverse cholesterol transport and increased inflammation. Circ Res. 2005; 97(8):763-71. DOI: 10.1161/01.RES.0000185320.82962.F7. View

Gordon D, Rifkind B . High-density lipoprotein--the clinical implications of recent studies. N Engl J Med. 1989; 321(19):1311-6. DOI: 10.1056/NEJM198911093211907. View

Shao B, Bergt C, Fu X, Green P, Voss J, Oda M . Tyrosine 192 in apolipoprotein A-I is the major site of nitration and chlorination by myeloperoxidase, but only chlorination markedly impairs ABCA1-dependent cholesterol transport. J Biol Chem. 2004; 280(7):5983-93. DOI: 10.1074/jbc.M411484200. View

10.

Terasaka N, Yu S, Yvan-Charvet L, Wang N, Mzhavia N, Langlois R . ABCG1 and HDL protect against endothelial dysfunction in mice fed a high-cholesterol diet. J Clin Invest. 2008; 118(11):3701-13. PMC: 2567835. DOI: 10.1172/JCI35470. View

11.

Bergt C, Pennathur S, Fu X, Byun J, OBrien K, McDonald T . The myeloperoxidase product hypochlorous acid oxidizes HDL in the human artery wall and impairs ABCA1-dependent cholesterol transport. Proc Natl Acad Sci U S A. 2004; 101(35):13032-7. PMC: 516512. DOI: 10.1073/pnas.0405292101. View

12.

Gaut J, Yeh G, Tran H, Byun J, Henderson J, Richter G . Neutrophils employ the myeloperoxidase system to generate antimicrobial brominating and chlorinating oxidants during sepsis. Proc Natl Acad Sci U S A. 2001; 98(21):11961-6. PMC: 59821. DOI: 10.1073/pnas.211190298. View

13.

Van Lenten B, Navab M, Shih D, Fogelman A, Lusis A . The role of high-density lipoproteins in oxidation and inflammation. Trends Cardiovasc Med. 2001; 11(3-4):155-61. DOI: 10.1016/s1050-1738(01)00095-0. View

14.

Nicholls S, Dusting G, Cutri B, Bao S, Drummond G, Rye K . Reconstituted high-density lipoproteins inhibit the acute pro-oxidant and proinflammatory vascular changes induced by a periarterial collar in normocholesterolemic rabbits. Circulation. 2005; 111(12):1543-50. DOI: 10.1161/01.CIR.0000159351.95399.50. View

15.

Vohl M, Neville T, Kumarathasan R, Braschi S, Sparks D . A novel lecithin-cholesterol acyltransferase antioxidant activity prevents the formation of oxidized lipids during lipoprotein oxidation. Biochemistry. 1999; 38(19):5976-81. DOI: 10.1021/bi982258w. View

16.

Hou X, Roberts 2nd L, Taber D, Morrow J, Kanai K, Gobeil Jr F . 2,3-Dinor-5,6-dihydro-15-F(2t)-isoprostane: a bioactive prostanoid metabolite. Am J Physiol Regul Integr Comp Physiol. 2001; 281(2):R391-400. DOI: 10.1152/ajpregu.2001.281.2.R391. View

17.

Shao B, Fu X, McDonald T, Green P, Uchida K, OBrien K . Acrolein impairs ATP binding cassette transporter A1-dependent cholesterol export from cells through site-specific modification of apolipoprotein A-I. J Biol Chem. 2005; 280(43):36386-96. DOI: 10.1074/jbc.M508169200. View

18.

Kontush A, Chapman M . Functionally defective high-density lipoprotein: a new therapeutic target at the crossroads of dyslipidemia, inflammation, and atherosclerosis. Pharmacol Rev. 2006; 58(3):342-74. DOI: 10.1124/pr.58.3.1. View

19.

Lawson J, Rokach J, FitzGerald G . Isoprostanes: formation, analysis and use as indices of lipid peroxidation in vivo. J Biol Chem. 1999; 274(35):24441-4. DOI: 10.1074/jbc.274.35.24441. View

20.

Barter P, Nicholls S, Rye K, Anantharamaiah G, Navab M, Fogelman A . Antiinflammatory properties of HDL. Circ Res. 2004; 95(8):764-72. DOI: 10.1161/01.RES.0000146094.59640.13. View