The Role of High-density Lipoproteins in Oxidation and Inflammation

Overview

Journal Trends Cardiovasc Med

Specialty Cardiology & Vascular Diseases

Date 2001 Nov 1

PMID 11686006

Citations 35

Authors

B J Van Lenten

M Navab

D Shih

A M Fogelman

A J Lusis

Affiliations

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Abstract

High-density lipoproteins (HDL) in the basal state are anti-inflammatory, capable of destroying oxidized lipids that generate an inflammatory response. However, HDL during acute inflammation are altered and become pro-inflammatory. This "chameleon-like" nature of HDL is considered to be due to the complex composition of HDL. The data reviewed here demonstrate the key role of HDL in modulating inflammation and its implications for atherogenesis.

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