Importance of Methyl Donors During Reproduction

Overview

Journal Am J Clin Nutr

Publisher Elsevier

Specialty Nutritional Sciences

Date 2009 Jan 1

PMID 19116320

Citations 99

Authors

Steven H Zeisel

Affiliations

Soon will be listed here.

Abstract

Evidence is growing that optimal dietary intake of folate and choline (both involved in one-carbon transfer or methylation) is important for successful completion of fetal development. Significant portions of the population are eating diets low in one or both of these nutrients. Folates are important for normal neural tube closure in early gestation, and the efficacy of diet fortification with folic acid in reducing the incidence of neural tube defects is a major success story for public health nutrition. Similarly, maternal dietary choline is important for normal neural tube closure in the fetus and, later in gestation, for neurogenesis in the fetal hippocampus, with effects on memory that persist in adult offspring; higher choline intake is associated with enhanced memory performance. Although both folates and choline have many potentially independent mechanisms whereby they could influence fetal development, these 2 nutrients also have a common mechanism for action: altered methylation and related epigenetic effects on gene expression.

Citing Articles

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References

Meck W, Williams C . Characterization of the facilitative effects of perinatal choline supplementation on timing and temporal memory. Neuroreport. 1997; 8(13):2831-5. DOI: 10.1097/00001756-199709080-00005. View

Locker J, Reddy T, Lombardi B . DNA methylation and hepatocarcinogenesis in rats fed a choline-devoid diet. Carcinogenesis. 1986; 7(8):1309-12. DOI: 10.1093/carcin/7.8.1309. View

Vance D . Boehringer Mannheim Award lecture. Phosphatidylcholine metabolism: masochistic enzymology, metabolic regulation, and lipoprotein assembly. Biochem Cell Biol. 1990; 68(10):1151-65. DOI: 10.1139/o90-172. View

Selhub J, Seyoum E, Pomfret E, Zeisel S . Effects of choline deficiency and methotrexate treatment upon liver folate content and distribution. Cancer Res. 1991; 51(1):16-21. View

Robertson K, Wolffe A . DNA methylation in health and disease. Nat Rev Genet. 2001; 1(1):11-9. DOI: 10.1038/35049533. View

Wendel U, Bremer H . Betaine in the treatment of homocystinuria due to 5,10-methylenetetrahydrofolate reductase deficiency. Eur J Pediatr. 1984; 142(2):147-50. DOI: 10.1007/BF00445602. View

Beaudin A, Stover P . Folate-mediated one-carbon metabolism and neural tube defects: balancing genome synthesis and gene expression. Birth Defects Res C Embryo Today. 2007; 81(3):183-203. DOI: 10.1002/bdrc.20100. View

Zeisel S, Mar M, Zhou Z, da Costa K . Pregnancy and lactation are associated with diminished concentrations of choline and its metabolites in rat liver. J Nutr. 1995; 125(12):3049-54. DOI: 10.1093/jn/125.12.3049. View

Zhu X, Mar M, Song J, Zeisel S . Deletion of the Pemt gene increases progenitor cell mitosis, DNA and protein methylation and decreases calretinin expression in embryonic day 17 mouse hippocampus. Brain Res Dev Brain Res. 2004; 149(2):121-9. DOI: 10.1016/j.devbrainres.2004.01.004. View

10.

Fisher M, Zeisel S, Mar M, Sadler T . Perturbations in choline metabolism cause neural tube defects in mouse embryos in vitro. FASEB J. 2002; 16(6):619-21. DOI: 10.1096/fj.01-0564fje. View

11.

Jones P, Gonzalgo M . Altered DNA methylation and genome instability: a new pathway to cancer?. Proc Natl Acad Sci U S A. 1997; 94(6):2103-5. PMC: 33658. DOI: 10.1073/pnas.94.6.2103. View

12.

Relton C, Wilding C, Laffling A, Jonas P, Burgess T, Binks K . Low erythrocyte folate status and polymorphic variation in folate-related genes are associated with risk of neural tube defect pregnancy. Mol Genet Metab. 2004; 81(4):273-81. DOI: 10.1016/j.ymgme.2003.12.010. View

13.

Persad V, Van den Hof M, Dube J, Zimmer P . Incidence of open neural tube defects in Nova Scotia after folic acid fortification. CMAJ. 2002; 167(3):241-5. PMC: 117468. View

14.

Shivapurkar N, Poirier L . Tissue levels of S-adenosylmethionine and S-adenosylhomocysteine in rats fed methyl-deficient, amino acid-defined diets for one to five weeks. Carcinogenesis. 1983; 4(8):1051-7. DOI: 10.1093/carcin/4.8.1051. View

15.

Cho E, Willett W, Colditz G, Fuchs C, Wu K, Chan A . Dietary choline and betaine and the risk of distal colorectal adenoma in women. J Natl Cancer Inst. 2007; 99(16):1224-31. PMC: 2441932. DOI: 10.1093/jnci/djm082. View

16.

Bidulescu A, Chambless L, Siega-Riz A, Zeisel S, Heiss G . Usual choline and betaine dietary intake and incident coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) study. BMC Cardiovasc Disord. 2007; 7:20. PMC: 1934379. DOI: 10.1186/1471-2261-7-20. View

17.

Blusztajn J, Wurtman R . Choline and cholinergic neurons. Science. 1983; 221(4611):614-20. DOI: 10.1126/science.6867732. View

18.

McVean G, Spencer C, Chaix R . Perspectives on human genetic variation from the HapMap Project. PLoS Genet. 2005; 1(4):e54. PMC: 1270010. DOI: 10.1371/journal.pgen.0010054. View

19.

van Praag H, Kempermann G, Gage F . Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nat Neurosci. 1999; 2(3):266-70. DOI: 10.1038/6368. View

20.

Motulsky A . Nutritional ecogenetics: homocysteine-related arteriosclerotic vascular disease, neural tube defects, and folic acid. Am J Hum Genet. 1996; 58(1):17-20. PMC: 1914958. View