Personalized Nutrition in the Management of Female Infertility: New Insights on Chronic Low-Grade Inflammation

Overview

Journal Nutrients

Date 2022 May 14

PMID 35565885

Authors

Gemma Fabozzi

Giulia Verdone

Mariachiara Allori

Danilo Cimadomo

Carla Tatone

Liborio Stuppia

Marica Franzago

Nicolo Ubaldi

Alberto Vaiarelli

Filippo Maria Ubaldi

Laura Rienzi

Gianluca Gennarelli

Affiliations

Soon will be listed here.

Abstract

Increasing evidence on the significance of nutrition in reproduction is emerging from both animal and human studies, suggesting a mutual association between nutrition and female fertility. Different "fertile" dietary patterns have been studied; however, in humans, conflicting results or weak correlations are often reported, probably because of the individual variations in genome, proteome, metabolome, and microbiome and the extent of exposure to different environmental conditions. In this scenario, "precision nutrition", namely personalized dietary patterns based on deep phenotyping and on metabolomics, microbiome, and nutrigenetics of each case, might be more efficient for infertile patients than applying a generic nutritional approach. In this review, we report on new insights into the nutritional management of infertile patients, discussing the main nutrigenetic, nutrigenomic, and microbiomic aspects that should be investigated to achieve effective personalized nutritional interventions. Specifically, we will focus on the management of low-grade chronic inflammation, which is associated with several infertility-related diseases.

Citing Articles

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