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Tetrahydrobiopterin Metabolism in the Temporal Lobe of Patients Dying with Senile Dementia of Alzheimer Type

Overview
Journal J Neurol Neurosurg Psychiatry
Publisher BMJ Publishing Group
Specialties Neurology
Neurosurgery
Psychiatry
Date 1984 Jul 1
PMID 6747650
Citations 19
Authors
P A Barford
J A Blair
C Eggar
C Hamon
C Morar
S B Whitburn
Affiliations
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Abstract

There is a defect in tetrahydrobiopterin metabolism in brains from subjects with senile dementia of Alzheimer type compared to age-matched controls. This defect results in lowered total biopterin concentrations in brain. Brains from subjects with senile dementia of Alzheimer type retain their ability to synthesis neopterin and have normal dihydropteridine reductase activity, indicating a specific loss of ability to convert dihydroneopterin triphosphate to tetrahydrobiopterin.

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