Endothelial Cells in Allograft Rejection

Overview

Journal Transplantation

Specialty General Surgery

Date 2008 Nov 27

PMID 19034000

Citations 50

Authors

Rafia S Al-Lamki

John R Bradley

Jordan S Pober

Affiliations

Soon will be listed here.

Abstract

In organ transplantation, blood borne cells and macromolecules (e.g., antibodies) of the host immune system are brought into direct contact with the endothelial cell lining of graft vessels. In this location, graft endothelial cells play several roles in allograft rejection, including the initiation of rejection responses by presentation of alloantigen to circulating T cells; the development of inflammation and thrombosis; and as targets of injury and agents of repair.

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References

Schlichting C, Schareck W, Weis M . Renal ischemia-reperfusion injury: new implications of dendritic cell-endothelial cell interactions. Transplant Proc. 2006; 38(3):670-3. DOI: 10.1016/j.transproceed.2006.01.059. View

Carlos T, Kovach N, Schwartz B, Rosa M, Newman B, Wayner E . Human monocytes bind to two cytokine-induced adhesive ligands on cultured human endothelial cells: endothelial-leukocyte adhesion molecule-1 and vascular cell adhesion molecule-1. Blood. 1991; 77(10):2266-71. View

Miller D, Yaron R, Yellin M . CD40L-CD40 interactions regulate endothelial cell surface tissue factor and thrombomodulin expression. J Leukoc Biol. 1998; 63(3):373-9. DOI: 10.1002/jlb.63.3.373. View

Migone T, Zhang J, Luo X, Zhuang L, Chen C, Hu B . TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator. Immunity. 2002; 16(3):479-92. DOI: 10.1016/s1074-7613(02)00283-2. View

Brodsky S, Zhang F, Nasjletti A, Goligorsky M . Endothelium-derived microparticles impair endothelial function in vitro. Am J Physiol Heart Circ Physiol. 2004; 286(5):H1910-5. DOI: 10.1152/ajpheart.01172.2003. View

Li J, Pober J . The cathepsin B death pathway contributes to TNF plus IFN-gamma-mediated human endothelial injury. J Immunol. 2005; 175(3):1858-66. DOI: 10.4049/jimmunol.175.3.1858. View

Game D, Lechler R . Pathways of allorecognition: implications for transplantation tolerance. Transpl Immunol. 2002; 10(2-3):101-8. DOI: 10.1016/s0966-3274(02)00055-2. View

Luster A, Unkeless J, Ravetch J . Gamma-interferon transcriptionally regulates an early-response gene containing homology to platelet proteins. Nature. 1985; 315(6021):672-6. DOI: 10.1038/315672a0. View

Pober J, Gimbrone Jr M, Collins T, COTRAN R, Ault K, Fiers W . Interactions of T lymphocytes with human vascular endothelial cells: role of endothelial cells surface antigens. Immunobiology. 1984; 168(3-5):483-94. DOI: 10.1016/s0171-2985(84)80132-1. View

10.

Tinckam K, Chandraker A . Mechanisms and role of HLA and non-HLA alloantibodies. Clin J Am Soc Nephrol. 2007; 1(3):404-14. DOI: 10.2215/CJN.00270106. View

11.

Yoshizumi M, Perrella M, Burnett Jr J, Lee M . Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life. Circ Res. 1993; 73(1):205-9. DOI: 10.1161/01.res.73.1.205. View

12.

Bender J, Pardi R, Engleman E . T-cell receptor-negative natural killer cells display antigen-specific cytotoxicity for microvascular endothelial cells. Proc Natl Acad Sci U S A. 1990; 87(18):6949-53. PMC: 54659. DOI: 10.1073/pnas.87.18.6949. View

13.

Strieter R, Kunkel S, Showell H, Remick D, Phan S, Ward P . Endothelial cell gene expression of a neutrophil chemotactic factor by TNF-alpha, LPS, and IL-1 beta. Science. 1989; 243(4897):1467-9. DOI: 10.1126/science.2648570. View

14.

Fiers W, Pober J . Membrane interleukin 1 induction on human endothelial cells and dermal fibroblasts. J Immunol. 1987; 139(7):2317-24. View

15.

SHINKAI A, Yoshisue H, Koike M, Shoji E, Nakagawa S, Saito A . A novel human CC chemokine, eotaxin-3, which is expressed in IL-4-stimulated vascular endothelial cells, exhibits potent activity toward eosinophils. J Immunol. 1999; 163(3):1602-10. View

16.

Oppenheim J, Tewary P, de la Rosa G, Yang D . Alarmins initiate host defense. Adv Exp Med Biol. 2007; 601:185-94. DOI: 10.1007/978-0-387-72005-0_19. View

17.

Manes T, Pober J . Antigen presentation by human microvascular endothelial cells triggers ICAM-1-dependent transendothelial protrusion by, and fractalkine-dependent transendothelial migration of, effector memory CD4+ T cells. J Immunol. 2008; 180(12):8386-92. PMC: 2435282. DOI: 10.4049/jimmunol.180.12.8386. View

18.

Wasowska B, Lee C, Halushka M, Baldwin 3rd W . New concepts of complement in allorecognition and graft rejection. Cell Immunol. 2007; 248(1):18-30. PMC: 2139895. DOI: 10.1016/j.cellimm.2007.04.009. View

19.

Dengler T, Pober J . Human vascular endothelial cells stimulate memory but not naive CD8+ T cells to differentiate into CTL retaining an early activation phenotype. J Immunol. 2000; 164(10):5146-55. DOI: 10.4049/jimmunol.164.10.5146. View

20.

Lang R . Macrophages induce apoptosis in normal cells in vivo. Development. 1997; 124(18):3633-8. DOI: 10.1242/dev.124.18.3633. View