Extracellular Vesicle-Associated TWEAK Contributes to Vascular Inflammation and Remodeling During Acute Cellular Rejection

Overview

Journal JACC Basic Transl Sci

Date 2023 Jun 16

PMID 37325400

Authors

Selvi Celik

Julia Sadrian

Mario Grossi

Tomasz Czuba

Jakob Lundgren

Goran Radegran

Thomas Laurell

J Gustav Smith

Olof Gidlof

Affiliations

Soon will be listed here.

Abstract

Acute cellular rejection (ACR) is a leading cause of graft loss and death after heart transplantation despite effective immunosuppressive therapies. The identification of factors that impair graft vascular barrier function or promote immune cell recruitment during ACR could provide new therapeutic opportunities for the treatment of patients who receive transplants. In 2 ACR cohorts, we found the extracellular vesicle-associated cytokine TWEAK to be elevated during ACR. Vesicular TWEAK promoted expression of proinflammatory genes and the release of chemoattractant cytokines from human cardiac endothelial cells. We conclude that vesicular TWEAK is a novel target with potential therapeutic implications in ACR.

Citing Articles

Circulating extracellular vesicles as biomarkers in the diagnosis, prognosis and therapy of cardiovascular diseases.

Bernath-Nagy D, Kalinyaprak M, Giannitsis E, Abraham P, Leuschner F, Frey N Front Cardiovasc Med. 2024; 11:1425159.

PMID: 39314768 PMC: 11417624. DOI: 10.3389/fcvm.2024.1425159.

Extracellular Vesicles as Bridges Between Host Immune Cells and Graft Organ During Cellular Rejection.

Barile L JACC Basic Transl Sci. 2023; 8(5):457-459.

PMID: 37325403 PMC: 10264701. DOI: 10.1016/j.jacbts.2023.01.015.

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