Recurrent Chromosomal Abnormalities in Human Embryonic Stem Cells

Overview

Journal Nat Biotechnol

Specialty Biotechnology

Date 2008 Nov 26

PMID 19029912

Citations 117

Authors

Claudia Spits

Ileana Mateizel

Mieke Geens

Afroditi Mertzanidou

Catherine Staessen

Yves Vandeskelde

Josiane Van der Elst

Inge Liebaers

Karen Sermon

Affiliations

Soon will be listed here.

Abstract

Cultured human embryonic stem (hES) cells have a known predisposition to aneuploidy of chromosomes 12, 17 and X. We studied 17 hES cell lines by array-based comparative genomic hybridization (aCGH) and found that the cells accumulate other recurrent chromosomal abnormalities, including amplification at 20q11.21 and a derivative chromosome 18. These genomic changes have a variable impact at the transcriptional level.

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