Helicobacter Pylori Virulence and the Diversity of Gastric Cancer in Asia

Overview

Journal J Med Microbiol

Specialty Microbiology

Date 2008 Nov 20

PMID 19018013

Citations 27

Authors

Lam Tung Nguyen

Tomohisa Uchida

Kazunari Murakami

Toshio Fujioka

Masatsugu Moriyama

Affiliations

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Abstract

Infection with cagPAI positive strains of Helicobacter pylori is recognized as being associated with an increased risk of gastric cancer. This article reviews the current knowledge on the structures and pathological functions of cagPAI and the CagA protein, focusing especially on the molecular mechanism through which CagA may be involved in gastric carcinogenesis. The possible link between the geographical distribution of cagPAI and cagA variations and gastric cancer diversity in Asia is also discussed.

Citing Articles

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Ghadersoltani P, Shoraka S, Sadjadi A, Saniee P BMC Gastroenterol. 2024; 24(1):466.

PMID: 39702056 PMC: 11660904. DOI: 10.1186/s12876-024-03516-0.

Curcumin Oxidation Is Required for Inhibition of Growth, Translocation and Phosphorylation of Cag A.

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Characterization of East-Asian Helicobacter pylori encoding Western EPIYA-ABC CagA.

Tissera K, Kim M, Lai J, Angulmaduwa S, Kim A, Merrell D J Microbiol. 2021; 60(2):207-214.

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EPIYA motifs of genotypes and gastrointestinal diseases in the Iranian population: a systematic review and meta-analysis.

Keikha M, Karbalaei M New Microbes New Infect. 2021; 41:100865.

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Precision Medicine Approaches to Prevent Gastric Cancer.

Matsuzaki J, Tsugawa H, Suzuki H Gut Liver. 2020; 15(1):3-12.

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