Shhh! Silencing by MicroRNA-155

Overview

Journal Philos Trans R Soc Lond B Biol Sci

Specialty Biology

Date 2008 Nov 15

PMID 19008191

Citations 33

Authors

Grace Teng

F Nina Papavasiliou

Affiliations

Soon will be listed here.

Abstract

Small RNAs mediate a diverse pot-pourri of post-transcriptional silencing mechanisms, ranging from 'classical' RNA interference (RNAi), to gene repression by microRNAs (miRNAs), to maintenance of genomic stability by repeat-associated small RNAs. Here, we review recent findings on the function of miR-155, particularly its roles in mammalian innate and adaptive immunity, viral infection and oncogenesis.

Citing Articles

Exploring the role of exosomal MicroRNAs as potential biomarkers in preeclampsia.

Shan Y, Hou B, Wang J, Chen A, Liu S Front Immunol. 2024; 15:1385950.

PMID: 38566996 PMC: 10985148. DOI: 10.3389/fimmu.2024.1385950.

Cis-regulatory mutations associate with transcriptional and post-transcriptional deregulation of gene regulatory programs in cancers.

Castro-Mondragon J, Aure M, Lingjaerde O, Langerod A, Martens J, Borresen-Dale A Nucleic Acids Res. 2022; 50(21):12131-12148.

PMID: 36477895 PMC: 9757053. DOI: 10.1093/nar/gkac1143.

Epigenetic processes during preeclampsia and effects on fetal development and chronic health.

Ashraf U, Hall D, Rawls A, Alexander B Clin Sci (Lond). 2021; 135(19):2307-2327.

PMID: 34643675 PMC: 8948502. DOI: 10.1042/CS20190070.

The Impact of microRNAs in Renin-Angiotensin-System-Induced Cardiac Remodelling.

Adamcova M, Kawano I, Simko F Int J Mol Sci. 2021; 22(9).

PMID: 33946230 PMC: 8124994. DOI: 10.3390/ijms22094762.

Effect of lentivirus-mediated miR-182 targeting FGF9 on hallux valgus.

Zhang W, Zhao D, Zhao W, Cui Y, Li Q, Zhang Z Int J Med Sci. 2021; 18(4):902-910.

PMID: 33456347 PMC: 7807199. DOI: 10.7150/ijms.50984.

References

McKercher S, Torbett B, Anderson K, Henkel G, Vestal D, Baribault H . Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities. EMBO J. 1996; 15(20):5647-58. PMC: 452309. View

Clurman B, Hayward W . Multiple proto-oncogene activations in avian leukosis virus-induced lymphomas: evidence for stage-specific events. Mol Cell Biol. 1989; 9(6):2657-64. PMC: 362338. DOI: 10.1128/mcb.9.6.2657-2664.1989. View

Mansfield J, Harfe B, Nissen R, Obenauer J, Srineel J, Chaudhuri A . MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression. Nat Genet. 2004; 36(10):1079-83. DOI: 10.1038/ng1421. View

Costinean S, Zanesi N, Pekarsky Y, Tili E, Volinia S, Heerema N . Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in E(mu)-miR155 transgenic mice. Proc Natl Acad Sci U S A. 2006; 103(18):7024-9. PMC: 1459012. DOI: 10.1073/pnas.0602266103. View

Krek A, Grun D, Poy M, Wolf R, Rosenberg L, Epstein E . Combinatorial microRNA target predictions. Nat Genet. 2005; 37(5):495-500. DOI: 10.1038/ng1536. View

Vigorito E, Perks K, Abreu-Goodger C, Bunting S, Xiang Z, Kohlhaas S . microRNA-155 regulates the generation of immunoglobulin class-switched plasma cells. Immunity. 2007; 27(6):847-59. PMC: 4135426. DOI: 10.1016/j.immuni.2007.10.009. View

Skalsky R, Samols M, Plaisance K, Boss I, Riva A, Lopez M . Kaposi's sarcoma-associated herpesvirus encodes an ortholog of miR-155. J Virol. 2007; 81(23):12836-45. PMC: 2169101. DOI: 10.1128/JVI.01804-07. View

Hammond S, Bernstein E, Beach D, Hannon G . An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells. Nature. 2000; 404(6775):293-6. DOI: 10.1038/35005107. View

Bernstein E, Caudy A, Hammond S, Hannon G . Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature. 2001; 409(6818):363-6. DOI: 10.1038/35053110. View

10.

Lee Y, Jeon K, Lee J, Kim S, Kim V . MicroRNA maturation: stepwise processing and subcellular localization. EMBO J. 2002; 21(17):4663-70. PMC: 126204. DOI: 10.1093/emboj/cdf476. View

11.

Scott E, Simon M, Anastasi J, Singh H . Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages. Science. 1994; 265(5178):1573-7. DOI: 10.1126/science.8079170. View

12.

Eis P, Tam W, Sun L, Chadburn A, Li Z, Gomez M . Accumulation of miR-155 and BIC RNA in human B cell lymphomas. Proc Natl Acad Sci U S A. 2005; 102(10):3627-32. PMC: 552785. DOI: 10.1073/pnas.0500613102. View

13.

Gironella M, Seux M, Xie M, Cano C, Tomasini R, Gommeaux J . Tumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its restoration inhibits pancreatic tumor development. Proc Natl Acad Sci U S A. 2007; 104(41):16170-5. PMC: 2042180. DOI: 10.1073/pnas.0703942104. View

14.

Guo S, Kemphues K . par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed. Cell. 1995; 81(4):611-20. DOI: 10.1016/0092-8674(95)90082-9. View

15.

Pfeffer S, Zavolan M, Grasser F, Chien M, Russo J, Ju J . Identification of virus-encoded microRNAs. Science. 2004; 304(5671):734-6. DOI: 10.1126/science.1096781. View

16.

Thai T, Calado D, Casola S, Ansel K, Xiao C, Xue Y . Regulation of the germinal center response by microRNA-155. Science. 2007; 316(5824):604-8. DOI: 10.1126/science.1141229. View

17.

Kiss T . Small nucleolar RNA-guided post-transcriptional modification of cellular RNAs. EMBO J. 2001; 20(14):3617-22. PMC: 125535. DOI: 10.1093/emboj/20.14.3617. View

18.

Pfeffer S, Sewer A, Lagos-Quintana M, Sheridan R, Sander C, Grasser F . Identification of microRNAs of the herpesvirus family. Nat Methods. 2005; 2(4):269-76. DOI: 10.1038/nmeth746. View

19.

Muramatsu M, Sankaranand V, Anant S, Sugai M, Kinoshita K, Davidson N . Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells. J Biol Chem. 1999; 274(26):18470-6. DOI: 10.1074/jbc.274.26.18470. View

20.

Martin M, Lee E, Buckenberger J, Schmittgen T, Elton T . MicroRNA-155 regulates human angiotensin II type 1 receptor expression in fibroblasts. J Biol Chem. 2006; 281(27):18277-84. DOI: 10.1074/jbc.M601496200. View