Novel Oxime and Oxime Ether Derivatives of 12,14-dichlorodehydroabietic Acid: Design, Synthesis, and BK Channel-opening Activity

Overview

Journal Bioorg Med Chem Lett

Specialty Biochemistry

Date 2008 Nov 8

PMID 18990575

Citations 3

Authors

Yong-Mei Cui

Eriko Yasutomi

Yuko Otani

Takashi Yoshinaga

Katsutoshi Ido

Kohei Sawada

Masatoshi Kawahata

Kentaro Yamaguchi

Tomohiko Ohwada

Affiliations

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Abstract

Oxime ether derivatives of the benzylic ketone of 12,14-dichlorodehydroabietic acid (diCl-DHAA, 4b) were synthesised, and their BK channel-opening activity was evaluated in an assay system of CHO-K1 cells expressing hBKalpha channels. Oxime ether structure on the B ring of diCl-DHAA significantly increased the BK channel-opening activity.

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