The Influence of Ghrelin, Adiponectin, and Leptin on Bone Mineral Density in Healthy Postmenopausal Women

Overview

Journal J Bone Miner Metab

Specialty Endocrinology

Date 2008 Nov 4

PMID 18979162

Citations 42

Authors

Jaak Jurimae

Toivo Jurimae

Aire Leppik

Tatjana Kums

Affiliations

Soon will be listed here.

Abstract

The association of body fat mass (FM) with bone mineral mass (BMC) and bone mineral density (BMD) has been attributed to a mechanical load exerted on the skeleton by FM and by the effect of different hormones. The aim of the present study was to determine whether there is a relationship between ghrelin, adiponectin, and leptin with BMC and BMD in healthy postmenopausal women (n = 88; age, 68.9 +/- 6.8 years; body mass index, 27.4 +/- 3.6 kg/m(2)). Body composition, BMC, and BMD were derived by dual-energy X-ray absorptiometry. Waist-to-hip (WHR) and waist-to-thigh (WTR) ratios were also obtained. Ghrelin was associated with total BMC (beta = -0.945; P = 0.0001), total BMD (beta = -0.959; P = 0.0001), lumbar spine BMD (beta = -0.945; P = 0.0001), and femoral neck BMD (beta = -0.957; P = 0.0001), and remained associated (P < 0.041) in different analyses that controlled for measured body composition and hormonal and insulin resistance values. However, the associations between ghrelin and measured bone mineral values were no longer significant (P > 0.149) when adjusted for body fat distribution values (WHR, WTR). Adiponectin was significantly related to total BMC (beta = -0.931; P = 0.0001), total BMD (beta = -0.940; P = 0.0001), lumbar spine BMD (beta = -0.937; P = 0.0001), and femoral neck BMD (beta = -0.940; P = 0.0001) values, and these relationships remained significant (P < 0.019) after adjusting for measured body fat, hormonal, and insulin resistance values but not when adjusted for fat-free mass (FFM; P > 0.106). In addition, significant associations of leptin with total BMC (beta = 0.912; P = 0.0001), total BMD (beta = 0.907; P = 0.0001), lumbar spine BMD (beta = 0.899; P = 0.0001), and femoral neck BMD (beta = 0.906; P = 0.0001) were found. These associations remained significant (P < 0.010) in different analyses that controlled for hormonal and insulin resistance values, but the associations between leptin and bone mineral values were no longer significant (P > 0.145) when adjusted for specific body composition values (WHR, WTR, FM, and FFM). In conclusion, it appears that the influence of plasma ghrelin, adiponectin, and leptin levels on BMC and BMD values is mediated or confounded by the specific body composition parameters in healthy postmenopausal women.

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References

Matsubara M, Maruoka S, Katayose S . Inverse relationship between plasma adiponectin and leptin concentrations in normal-weight and obese women. Eur J Endocrinol. 2002; 147(2):173-80. DOI: 10.1530/eje.0.1470173. View

Ravn P, Cizza G, Bjarnason N, Thompson D, Daley M, Wasnich R . Low body mass index is an important risk factor for low bone mass and increased bone loss in early postmenopausal women. Early Postmenopausal Intervention Cohort (EPIC) study group. J Bone Miner Res. 1999; 14(9):1622-7. DOI: 10.1359/jbmr.1999.14.9.1622. View

Whipple T, Sharkey N, Demers L, Williams N . Leptin and the skeleton. Clin Endocrinol (Oxf). 2002; 57(6):701-11. DOI: 10.1046/j.1365-2265.2002.01630.x. View

Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K . Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature. 1999; 402(6762):656-60. DOI: 10.1038/45230. View

Shinoda Y, Yamaguchi M, Ogata N, Akune T, Kubota N, Yamauchi T . Regulation of bone formation by adiponectin through autocrine/paracrine and endocrine pathways. J Cell Biochem. 2006; 99(1):196-208. DOI: 10.1002/jcb.20890. View

Oshima K, Nampei A, Matsuda M, Iwaki M, Fukuhara A, Hashimoto J . Adiponectin increases bone mass by suppressing osteoclast and activating osteoblast. Biochem Biophys Res Commun. 2005; 331(2):520-6. DOI: 10.1016/j.bbrc.2005.03.210. View

Reid I . Relationships among body mass, its components, and bone. Bone. 2002; 31(5):547-55. DOI: 10.1016/s8756-3282(02)00864-5. View

Lenchik L, Register T, Hsu F, Lohman K, Nicklas B, Freedman B . Adiponectin as a novel determinant of bone mineral density and visceral fat. Bone. 2003; 33(4):646-51. DOI: 10.1016/s8756-3282(03)00237-0. View

Harris S, Dallal G, Dawson-Hughes B . Influence of body weight on rates of change in bone density of the spine, hip, and radius in postmenopausal women. Calcif Tissue Int. 1992; 50(1):19-23. DOI: 10.1007/BF00297292. View

10.

Fukushima N, Hanada R, Teranishi H, Fukue Y, Tachibana T, Ishikawa H . Ghrelin directly regulates bone formation. J Bone Miner Res. 2005; 20(5):790-8. DOI: 10.1359/JBMR.041237. View

11.

Berner H, Lyngstadaas S, Spahr A, Monjo M, Thommesen L, Drevon C . Adiponectin and its receptors are expressed in bone-forming cells. Bone. 2004; 35(4):842-9. DOI: 10.1016/j.bone.2004.06.008. View

12.

Haqq A, Farooqi I, ORahilly S, Stadler D, Rosenfeld R, Pratt K . Serum ghrelin levels are inversely correlated with body mass index, age, and insulin concentrations in normal children and are markedly increased in Prader-Willi syndrome. J Clin Endocrinol Metab. 2003; 88(1):174-8. DOI: 10.1210/jc.2002-021052. View

13.

Lee W, Rhee E, Oh K, Kim S, Jung C, Yun E . Identification of adiponectin and its receptors in human osteoblast-like cells and association of T45G polymorphism in exon 2 of adiponectin gene with lumbar spine bone mineral density in Korean women. Clin Endocrinol (Oxf). 2006; 65(5):631-7. DOI: 10.1111/j.1365-2265.2006.02641.x. View

14.

Vilarrasa N, Vendrell J, Maravall J, Broch M, Estepa A, Megia A . Distribution and determinants of adiponectin, resistin and ghrelin in a randomly selected healthy population. Clin Endocrinol (Oxf). 2005; 63(3):329-35. DOI: 10.1111/j.1365-2265.2005.02346.x. View

15.

Bouchard C, Tremblay A, Leblanc C, Lortie G, Savard R, Theriault G . A method to assess energy expenditure in children and adults. Am J Clin Nutr. 1983; 37(3):461-7. DOI: 10.1093/ajcn/37.3.461. View

16.

Caminos J, Gualillo O, Lago F, Otero M, Blanco M, Gallego R . The endogenous growth hormone secretagogue (ghrelin) is synthesized and secreted by chondrocytes. Endocrinology. 2004; 146(3):1285-92. DOI: 10.1210/en.2004-1379. View

17.

Jurimae J, Jurimae T . Adiponectin is a predictor of bone mineral density in middle-aged premenopausal women. Osteoporos Int. 2007; 18(9):1253-9. DOI: 10.1007/s00198-007-0365-5. View

18.

Weyer C, Funahashi T, Tanaka S, Hotta K, Matsuzawa Y, Pratley R . Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab. 2001; 86(5):1930-5. DOI: 10.1210/jcem.86.5.7463. View

19.

Blain H, Vuillemin A, Guillemin F, Durant R, Hanesse B, De Talance N . Serum leptin level is a predictor of bone mineral density in postmenopausal women. J Clin Endocrinol Metab. 2002; 87(3):1030-5. DOI: 10.1210/jcem.87.3.8313. View

20.

Thomas T, Burguera B . Is leptin the link between fat and bone mass?. J Bone Miner Res. 2002; 17(9):1563-9. DOI: 10.1359/jbmr.2002.17.9.1563. View