Adiponectin is Associated with Bone Strength and Fracture History in Paralyzed Men with Spinal Cord Injury

Overview

Journal Osteoporos Int

Specialties Endocrinology
Orthopedics

Date 2014 Jul 2

PMID 24980185

Citations 13

Authors

C O Tan

R A Battaglino

A L Doherty

R Gupta

A A Lazzari

E Garshick

R Zafonte

L R Morse

Affiliations

Soon will be listed here.

Abstract

Unlabelled: We explored the association between adiponectin levels and bone strength in paralyzed men with spinal cord injury. We found that bone strength was inversely associated with circulating adiponectin levels. Thus, strength estimates and adiponectin levels may improve fracture risk prediction and detection of response to osteogenic therapies following spinal cord injury.

Purpose: Previous research has demonstrated an inverse relationship between circulating adiponectin and bone mineral density, suggesting that adiponectin may be used as a biomarker for bone health. However, this relationship may reflect indirect effects on bone metabolism via adipose-mediated mechanical pathways rather than the direct effects of adipokines on bone metabolism. Thus, we explored the association between circulating adiponectin levels and bone strength in 27 men with spinal cord injury.

Methods: Plasma adiponectin levels were quantified by ELISA assay. Axial stiffness and maximal load to fracture of the distal femur were quantified via finite element analysis using reconstructed 3D models of volumetric CT scans. We also collected information on timing, location, and cause of previous fractures.

Results: Axial stiffness and maximal load were inversely associated with circulating adiponectin levels (R (2) = 0.44, p = 0.01; R (2) = 0.58, p = 0.05) after adjusting for injury duration and lower extremity lean mass. In individuals with post-SCI osteoporotic fractures, distal femur stiffness (p = 0.01) and maximal load (p = 0.005) were lower, and adiponectin was higher (p = 0.04) than those with no fracture history.

Conclusions: Based on these findings, strength estimates may improve fracture risk prediction and detection of response to osteogenic therapies following spinal cord injury. Furthermore, our findings suggest that circulating adiponectin may indeed be a feasible biomarker for bone health and osteoporotic fracture risk in paralyzed individuals with spinal cord injury.

Citing Articles

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Adiponectin in spinal cord injury: What is the role of nutrition in serum adiponectin concentration?.

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Rehabilitation: Neurogenic Bone Loss after Spinal Cord Injury.

Leone G, Shields D, Haque A, Banik N Biomedicines. 2023; 11(9).

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Deepika F, Bathina S, Armamento-Villareal R Biomedicines. 2023; 11(2).

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Biomarkers from Secondary Complications in Spinal Cord Injury.

Alostaz H, Cai L Curr Pharmacol Rep. 2022; 8(1):20-30.

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References

Basurto L, Galvan R, Cordova N, Saucedo R, Vargas C, Campos S . Adiponectin is associated with low bone mineral density in elderly men. Eur J Endocrinol. 2008; 160(2):289-93. DOI: 10.1530/EJE-08-0569. View

Luo X, Guo L, Yuan L, Xie H, Zhou H, Wu X . Adiponectin stimulates human osteoblasts proliferation and differentiation via the MAPK signaling pathway. Exp Cell Res. 2005; 309(1):99-109. DOI: 10.1016/j.yexcr.2005.05.021. View

Peng X, Xie H, Zhao Q, Wu X, Sun Z, Liao E . Relationships between serum adiponectin, leptin, resistin, visfatin levels and bone mineral density, and bone biochemical markers in Chinese men. Clin Chim Acta. 2007; 387(1-2):31-5. DOI: 10.1016/j.cca.2007.08.012. View

Iacobellis G, Iorio M, Napoli N, Cotesta D, Zinnamosca L, Marinelli C . Relation of adiponectin, visfatin and bone mineral density in patients with metabolic syndrome. J Endocrinol Invest. 2010; 34(1):e12-5. DOI: 10.1007/BF03346703. View

Agbaht K, Gurlek A, Karakaya J, Bayraktar M . Circulating adiponectin represents a biomarker of the association between adiposity and bone mineral density. Endocrine. 2009; 35(3):371-9. DOI: 10.1007/s12020-009-9158-2. View

Morse L, Lazzari A, Battaglino R, Stolzmann K, Matthess K, Gagnon D . Dual energy x-ray absorptiometry of the distal femur may be more reliable than the proximal tibia in spinal cord injury. Arch Phys Med Rehabil. 2009; 90(5):827-31. PMC: 2677191. DOI: 10.1016/j.apmr.2008.12.004. View

Berner H, Lyngstadaas S, Spahr A, Monjo M, Thommesen L, Drevon C . Adiponectin and its receptors are expressed in bone-forming cells. Bone. 2004; 35(4):842-9. DOI: 10.1016/j.bone.2004.06.008. View

Wheater G, Elshahaly M, Tuck S, Datta H, van Laar J . The clinical utility of bone marker measurements in osteoporosis. J Transl Med. 2013; 11:201. PMC: 3765909. DOI: 10.1186/1479-5876-11-201. View

Dreiseitl S, Ohno-Machado L, Vinterbo S . Evaluating variable selection methods for diagnosis of myocardial infarction. Proc AMIA Symp. 1999; :246-50. PMC: 2232647. View

10.

Vestergaard P, Krogh K, Rejnmark L, Mosekilde L . Fracture rates and risk factors for fractures in patients with spinal cord injury. Spinal Cord. 1998; 36(11):790-6. DOI: 10.1038/sj.sc.3100648. View

11.

Tuukkanen J, Koivukangas A, Jamsa T, Sundquist K, MacKAY C, Marks Jr S . Mineral density and bone strength are dissociated in long bones of rat osteopetrotic mutations. J Bone Miner Res. 2000; 15(10):1905-11. DOI: 10.1359/jbmr.2000.15.10.1905. View

12.

Yokota T, Meka C, Medina K, Igarashi H, Comp P, Takahashi M . Paracrine regulation of fat cell formation in bone marrow cultures via adiponectin and prostaglandins. J Clin Invest. 2002; 109(10):1303-10. PMC: 2447671. DOI: 10.1172/JCI14506. View

13.

Barbour K, Zmuda J, Boudreau R, Strotmeyer E, Horwitz M, Evans R . The effects of adiponectin and leptin on changes in bone mineral density. Osteoporos Int. 2011; 23(6):1699-710. PMC: 3536828. DOI: 10.1007/s00198-011-1768-x. View

14.

Cody D, Gross G, Hou F, Spencer H, Goldstein S, Fyhrie D . Femoral strength is better predicted by finite element models than QCT and DXA. J Biomech. 1999; 32(10):1013-20. DOI: 10.1016/s0021-9290(99)00099-8. View

15.

Zhang Y, Zhou P, Kimondo J . Adiponectin and osteocalcin: relation to insulin sensitivity. Biochem Cell Biol. 2012; 90(5):613-20. DOI: 10.1139/o2012-022. View

16.

Johansson H, Oden A, Lerner U, Jutberger H, Lorentzon M, Barrett-Connor E . High serum adiponectin predicts incident fractures in elderly men: Osteoporotic fractures in men (MrOS) Sweden. J Bone Miner Res. 2012; 27(6):1390-6. DOI: 10.1002/jbmr.1591. View

17.

Li X, Ominsky M, Niu Q, Sun N, Daugherty B, DAgostin D . Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength. J Bone Miner Res. 2008; 23(6):860-9. DOI: 10.1359/jbmr.080216. View

18.

Richards J, Valdes A, Burling K, Perks U, Spector T . Serum adiponectin and bone mineral density in women. J Clin Endocrinol Metab. 2007; 92(4):1517-23. DOI: 10.1210/jc.2006-2097. View

19.

Baldock P . Reciprocal regulation of bone and energy metabolism. Horm Res Paediatr. 2011; 76 Suppl 1:7-11. DOI: 10.1159/000329134. View

20.

Morse L, Sudhakar S, Lazzari A, Tun C, Garshick E, Zafonte R . Sclerostin: a candidate biomarker of SCI-induced osteoporosis. Osteoporos Int. 2012; 24(3):961-8. PMC: 3611240. DOI: 10.1007/s00198-012-2072-0. View