Influence of Body Weight on Rates of Change in Bone Density of the Spine, Hip, and Radius in Postmenopausal Women

Overview

Journal Calcif Tissue Int

Specialty Pathology

Date 1992 Jan 1

PMID 1739865

Citations 24

Authors

S Harris

G E Dallal

B Dawson-Hughes

Affiliations

Soon will be listed here.

Abstract

Interrelationships between percent of ideal body weight (%IBW), serum estrogen levels, and change in bone mineral density (delta BMD) and bone mineral content (delta BMC) were studied in 288 postmenopausal women aged 41-71 years who participated in a 2-year calcium supplement trial. The spine (L2-L4) and femoral neck were measured by dualphoton absorptiometry, and the radius was measured by single-photon absorptiometry. Years since menopause, calcium intake, and initial BMD or BMC were included as independent variables in two-phase regressions of delta BMD and delta BMD on %IBW. Increased %IBW protected against loss of spine BMD [regression slope estimate = 0.05, 95% C.I.: (0.03, 0.26)] and BMC in women up through about 106 %IBW but not in heavier women. Increased %IBW was not significantly related to delta BMD or delta BMC at the femoral neck or radius. Women above 106 %IBW had significant gains in spine and femoral neck area (P less than 0.05). Serum estrone and estradiol were positively correlated with delta BMD and delta BMC at the femoral neck only.

Citing Articles

Longitudinal changes in bone mineral density during perimenopausal transition: the Vietnam Osteoporosis Study.

Ho-Pham L, Nguyen H, Nguyen-Pham S, Hoang D, Tran T, Nguyen T Osteoporos Int. 2023; 34(8):1381-1387.

PMID: 37106043 DOI: 10.1007/s00198-023-06757-z.

Quantitative ultrasound assessment of the effect of parity on bone mineral density in females.

Akil S, Al-Mohammed H, Al-Batati N, Tirsen M, Al-Otaibi A, AlZahrani A BMC Womens Health. 2021; 21(1):380.

PMID: 34717605 PMC: 8557593. DOI: 10.1186/s12905-021-01516-w.

Influence of Habitual Physical Behavior - Sleeping, Sedentarism, Physical Activity - On Bone Health in Community-Dwelling Older People.

Onambele-Pearson G, Wullems J, Doody C, Ryan D, Morse C, Degens H Front Physiol. 2019; 10:408.

PMID: 31037056 PMC: 6476278. DOI: 10.3389/fphys.2019.00408.

Lean Mass and Body Fat Percentage Are Contradictory Predictors of Bone Mineral Density in Pre-Menopausal Pacific Island Women.

Casale M, von Hurst P, Beck K, Shultz S, Kruger M, OBrien W Nutrients. 2016; 8(8).

PMID: 27483314 PMC: 4997383. DOI: 10.3390/nu8080470.

Exercise Regulation of Marrow Adipose Tissue.

Pagnotti G, Styner M Front Endocrinol (Lausanne). 2016; 7:94.

PMID: 27471493 PMC: 4943947. DOI: 10.3389/fendo.2016.00094.

References

Dawson-Hughes B, Deehr M, Berger P, Dallal G, Sadowski L . Correction of the effects of source, source strength, and soft-tissue thickness on spine dual-photon absorptiometry measurements. Calcif Tissue Int. 1989; 44(4):251-7. DOI: 10.1007/BF02553759. View

Christiansen C, Riis B, RODBRO P . Prediction of rapid bone loss in postmenopausal women. Lancet. 1987; 1(8542):1105-8. DOI: 10.1016/s0140-6736(87)91671-0. View

Luckey M, Meier D, Mandeli J, DaCosta M, Hubbard M, Goldsmith S . Radial and vertebral bone density in white and black women: evidence for racial differences in premenopausal bone homeostasis. J Clin Endocrinol Metab. 1989; 69(4):762-70. DOI: 10.1210/jcem-69-4-762. View

Longcope C, WATSON D, Williams K . The effects of synthetic estrogens on the metabolic clearance and production rates of estrone and estradiol. Steroids. 1974; 24(1):15-30. DOI: 10.1016/0039-128x(74)90042-7. View

Slemenda C, Hui S, Williams C, CHRISTIAN J, Meaney F, JOHNSTON Jr C . Bone mass and anthropometric measurements in adult females. Bone Miner. 1990; 11(1):101-9. DOI: 10.1016/0169-6009(90)90019-c. View

Slemenda C, Hui S, Longcope C, JOHNSTON C . Sex steroids and bone mass. A study of changes about the time of menopause. J Clin Invest. 1987; 80(5):1261-9. PMC: 442379. DOI: 10.1172/JCI113201. View

Schindler A, Ebert A, Friedrich E . Conversion of androstenedione to estrone by human tissue. J Clin Endocrinol Metab. 1972; 35(4):627-30. DOI: 10.1210/jcem-35-4-627. View

Longcope C, Baker R, JOHNSTON Jr C . Androgen and estrogen metabolism: relationship to obesity. Metabolism. 1986; 35(3):235-7. DOI: 10.1016/0026-0495(86)90206-4. View

Shipp C, Berger P, Deehr M, Dawson-Hughes B . Precision of dual-photon absorptiometry. Calcif Tissue Int. 1988; 42(5):287-92. DOI: 10.1007/BF02556361. View

10.

Nordin B, Chatterton B, Steurer T, Walker C . Forearm bone mineral content does not decline with age in premenopausal women. Clin Orthop Relat Res. 1986; (211):252-6. View

11.

Ribot C, Tremollieres F, Pouilles J, Bonneu M, Germain F, LOUVET J . Obesity and postmenopausal bone loss: the influence of obesity on vertebral density and bone turnover in postmenopausal women. Bone. 1987; 8(6):327-31. DOI: 10.1016/8756-3282(87)90062-7. View

12.

Krall E, Sahyoun N, Tannenbaum S, Dallal G, Dawson-Hughes B . Effect of vitamin D intake on seasonal variations in parathyroid hormone secretion in postmenopausal women. N Engl J Med. 1989; 321(26):1777-83. DOI: 10.1056/NEJM198912283212602. View

13.

Russell R, MCGANDY R, Jelliffe D . Reference weights. Practical considerations. Am J Med. 1984; 76(5):767-9. DOI: 10.1016/0002-9343(84)90983-5. View

14.

Pocock N, Eisman J, Gwinn T, Sambrook P, Kelly P, Freund J . Muscle strength, physical fitness, and weight but not age predict femoral neck bone mass. J Bone Miner Res. 1989; 4(3):441-8. DOI: 10.1002/jbmr.5650040320. View

15.

Riggs B, Wahner H, Melton 3rd L, Richelson L, Judd H, Offord K . Rates of bone loss in the appendicular and axial skeletons of women. Evidence of substantial vertebral bone loss before menopause. J Clin Invest. 1986; 77(5):1487-91. PMC: 424550. DOI: 10.1172/JCI112462. View

16.

Parfitt A . Age-related structural changes in trabecular and cortical bone: cellular mechanisms and biomechanical consequences. Calcif Tissue Int. 1984; 36 Suppl 1:S123-8. DOI: 10.1007/BF02406145. View

17.

Frumar A, Meldrum D, Geola F, Shamonki I, Tataryn I, Deftos L . Relationship of fasting urinary calcium to circulating estrogen and body weight in postmenopausal women. J Clin Endocrinol Metab. 1980; 50(1):70-5. DOI: 10.1210/jcem-50-1-70. View

18.

Rubin C, Lanyon L . Regulation of bone mass by mechanical strain magnitude. Calcif Tissue Int. 1985; 37(4):411-7. DOI: 10.1007/BF02553711. View

19.

Dawson-Hughes B, Dallal G . Effect of radiographic abnormalities on rate of bone loss from the spine. Calcif Tissue Int. 1990; 46(4):280-1. DOI: 10.1007/BF02555008. View

20.

Mosekilde L . Normal vertebral body size and compressive strength: relations to age and to vertebral and iliac trabecular bone compressive strength. Bone. 1986; 7(3):207-12. DOI: 10.1016/8756-3282(86)90019-0. View