SNAP: a Web-based Tool for Identification and Annotation of Proxy SNPs Using HapMap

Overview

Journal Bioinformatics

Publisher Oxford University Press

Specialty Biology

Date 2008 Nov 1

PMID 18974171

Citations 856

Authors

Andrew D Johnson

Robert E Handsaker

Sara L Pulit

Marcia M Nizzari

Christopher J ODonnell

Paul I W de Bakker

Affiliations

Soon will be listed here.

Abstract

Summary: The interpretation of genome-wide association results is confounded by linkage disequilibrium between nearby alleles. We have developed a flexible bioinformatics query tool for single-nucleotide polymorphisms (SNPs) to identify and to annotate nearby SNPs in linkage disequilibrium (proxies) based on HapMap. By offering functionality to generate graphical plots for these data, the SNAP server will facilitate interpretation and comparison of genome-wide association study results, and the design of fine-mapping experiments (by delineating genomic regions harboring associated variants and their proxies).

Availability: SNAP server is available at http://www.broad.mit.edu/mpg/snap/.

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