Colon Cancer Stem Cells: Implications for Prevention and Therapy

Overview

Journal Trends Mol Med

Specialties General Medicine
Molecular Biology

Date 2008 Oct 22

PMID 18929507

Citations 38

Authors

Emina H Huang

Max S Wicha

Affiliations

Soon will be listed here.

Abstract

The recent identification of colon cancer tumor-initiating cells adds further support to the cancer stem cell hypothesis. Ongoing basic and translational research efforts are aimed at gaining an increased understanding of the biology of these cells, as well as methods of targeting them. In addition, the relationship between colon carcinogenesis and inflammatory conditions, such as longstanding colitis and inherited syndromes, might be linked to the effect of the processes on stem cells in the colon. This review summarizes current literature on colon cancer stem cells and proposes strategies aimed at targeting these cells for colon cancer prevention and therapy.

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References

Eaden J, Abrams K, Mayberry J . The risk of colorectal cancer in ulcerative colitis: a meta-analysis. Gut. 2001; 48(4):526-35. PMC: 1728259. DOI: 10.1136/gut.48.4.526. View

Dalerba P, Dylla S, Park I, Liu R, Wang X, Cho R . Phenotypic characterization of human colorectal cancer stem cells. Proc Natl Acad Sci U S A. 2007; 104(24):10158-63. PMC: 1891215. DOI: 10.1073/pnas.0703478104. View

Bhatia M, Wang J, Kapp U, Bonnet D, Dick J . Purification of primitive human hematopoietic cells capable of repopulating immune-deficient mice. Proc Natl Acad Sci U S A. 1997; 94(10):5320-5. PMC: 24676. DOI: 10.1073/pnas.94.10.5320. View

Jin L, Hope K, Zhai Q, Smadja-Joffe F, Dick J . Targeting of CD44 eradicates human acute myeloid leukemic stem cells. Nat Med. 2006; 12(10):1167-74. DOI: 10.1038/nm1483. View

Loftus Jr E, Silverstein M, Sandborn W, Tremaine W, Harmsen W, Zinsmeister A . Ulcerative colitis in Olmsted County, Minnesota, 1940-1993: incidence, prevalence, and survival. Gut. 2000; 46(3):336-43. PMC: 1727835. DOI: 10.1136/gut.46.3.336. View

Shacter E, Weitzman S . Chronic inflammation and cancer. Oncology (Williston Park). 2002; 16(2):217-26, 229; discussion 230-2. View

Barker N, van Es J, Kuipers J, Kujala P, van den Born M, Cozijnsen M . Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature. 2007; 449(7165):1003-7. DOI: 10.1038/nature06196. View

Powell S, Zilz N, Bryan T, Hamilton S, Thibodeau S, Vogelstein B . APC mutations occur early during colorectal tumorigenesis. Nature. 1992; 359(6392):235-7. DOI: 10.1038/359235a0. View

Diaz-Rubio E . Vascular endothelial growth factor inhibitors in colon cancer. Adv Exp Med Biol. 2006; 587:251-75. DOI: 10.1007/978-1-4020-5133-3_20. View

10.

Todaro M, Perez Alea M, Di Stefano A, Cammareri P, Vermeulen L, Iovino F . Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4. Cell Stem Cell. 2008; 1(4):389-402. DOI: 10.1016/j.stem.2007.08.001. View

11.

Kuper H, Adami H, Trichopoulos D . Infections as a major preventable cause of human cancer. J Intern Med. 2000; 248(3):171-83. DOI: 10.1046/j.1365-2796.2000.00742.x. View

12.

Shmelkov S, St Clair R, Lyden D, Rafii S . AC133/CD133/Prominin-1. Int J Biochem Cell Biol. 2005; 37(4):715-9. DOI: 10.1016/j.biocel.2004.08.010. View

13.

Shmelkov S, Butler J, Hooper A, Hormigo A, Kushner J, Milde T . CD133 expression is not restricted to stem cells, and both CD133+ and CD133- metastatic colon cancer cells initiate tumors. J Clin Invest. 2008; 118(6):2111-20. PMC: 2391278. DOI: 10.1172/JCI34401. View

14.

Yilmaz O, Kiel M, Morrison S . SLAM family markers are conserved among hematopoietic stem cells from old and reconstituted mice and markedly increase their purity. Blood. 2005; 107(3):924-30. PMC: 1895895. DOI: 10.1182/blood-2005-05-2140. View

15.

Deng G, Lu Y, Zlotnikov G, Thor A, Smith H . Loss of heterozygosity in normal tissue adjacent to breast carcinomas. Science. 1996; 274(5295):2057-9. DOI: 10.1126/science.274.5295.2057. View

16.

OBrien C, Pollett A, Gallinger S, Dick J . A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature. 2006; 445(7123):106-10. DOI: 10.1038/nature05372. View

17.

Coussens L, Werb Z . Inflammation and cancer. Nature. 2002; 420(6917):860-7. PMC: 2803035. DOI: 10.1038/nature01322. View

18.

Yu F, Yao H, Zhu P, Zhang X, Pan Q, Gong C . let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell. 2007; 131(6):1109-23. DOI: 10.1016/j.cell.2007.10.054. View

19.

Itzkowitz S, Yio X . Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation. Am J Physiol Gastrointest Liver Physiol. 2004; 287(1):G7-17. DOI: 10.1152/ajpgi.00079.2004. View

20.

Chen R, Rabinovitch P, Crispin D, Emond M, Bronner M, Brentnall T . The initiation of colon cancer in a chronic inflammatory setting. Carcinogenesis. 2005; 26(9):1513-9. DOI: 10.1093/carcin/bgi106. View