Infections As a Major Preventable Cause of Human Cancer

Overview

Journal J Intern Med

Specialty General Medicine

Date 2000 Sep 6

PMID 10971784

Citations 309

Authors

H Kuper

H O Adami

D Trichopoulos

Affiliations

Soon will be listed here.

Abstract

Infections may be responsible for over 15% of all malignancies worldwide. Important mechanisms by which infectious agents may induce carcinogenesis include the production of chronic inflammation, the transformation of cells by insertion of oncogenes and inhibition of tumour suppressors, and the induction of immunosuppression. Common characteristics shared by infectious agents linked to malignancies are that they are persistent in the host, often highly prevalent in the host population and induce cancer after a long latency. The associations between a selection of infectious agents and malignancies are covered in detail.

Citing Articles

Potential Common Molecular Mechanisms Between Periodontitis and Prostate Cancer: A Network Analysis of Differentially Expressed miRNAs.

Kanli A, Sunnetci-Akkoyunlu D, Kulcu-Sarikaya N, Ugurtas C, Akpinar G, Kasap M In Vivo. 2025; 39(2):795-809.

PMID: 40010958 PMC: 11884493. DOI: 10.21873/invivo.13863.

Machine learning-based bulk RNA analysis reveals a prognostic signature of 13 cell death patterns and potential therapeutic target of SMAD3 in acute myeloid leukemia.

Bao X, Chen Y, Chang J, Du J, Yang C, Wu Y BMC Cancer. 2025; 25(1):273.

PMID: 39955536 PMC: 11830216. DOI: 10.1186/s12885-025-13658-3.

Significance of non-steroidal anti-inflammatory drugs in the prevention and treatment of cervical cancer.

Kan X, Zhou Z, Liu L, Aiskikaer R, Zou Y Heliyon. 2025; 11(3):e42055.

PMID: 39916829 PMC: 11800076. DOI: 10.1016/j.heliyon.2025.e42055.

The Prognostic Value of Peripheral Blood Inflammatory Markers in Hepatocellular Carcinoma Treated with Lenvatinib Combined with PD-1 Inhibitors.

Xin Y, Liu N, Peng G, Huang X, Cao X, Zhou X J Hepatocell Carcinoma. 2025; 12:135-147.

PMID: 39877858 PMC: 11774115. DOI: 10.2147/JHC.S486910.

Cardiovascular diseases in patients with cancer: A comprehensive review of epidemiological trends, cardiac complications, and prognostic implications.

Alshahrani A, Kontopantelis E, Morgan C, Ravindrarajah R, Martin G, Mamas M Chin Med J (Engl). 2024; 138(2):143-154.

PMID: 39719690 PMC: 11745857. DOI: 10.1097/CM9.0000000000003419.