About the Importance of Being Desulfated

Overview

Journal Genes Dev

Specialty Molecular Biology

Date 2008 Oct 17

PMID 18923073

Citations 3

Authors

Richa Khatri

Ernestina Schipani

Affiliations

Soon will be listed here.

Abstract

Sulfated proteoglycans have important structural and signaling functions in the growth plate. In the October 1, 2008, issue of Genes & Development, Settembre and colleagues (2645-2650) report that lack of SUMF1, a crucial enzyme in the activation of sulfatases, causes a severe chondrodysplasia by augmenting fibroblast growth factor signaling and by hampering the autophagic process, which the investigators show is constitutively on in chondrocytes. The findings highlight the essential role of desulfation in cartilage biology and organogenesis.

Citing Articles

Expression, activity and localization of lysosomal sulfatases in Chronic Obstructive Pulmonary Disease.

Weidner J, Jogdand P, Jarenback L, Aberg I, Helihel D, Ankerst J Sci Rep. 2019; 9(1):1991.

PMID: 30760748 PMC: 6374378. DOI: 10.1038/s41598-018-37958-w.

Posttranslational modifications of collagens as targets of hypoxia and Hif-1alpha in endochondral bone development.

Schipani E Ann N Y Acad Sci. 2010; 1192:317-21.

PMID: 20392253 PMC: 3047466. DOI: 10.1111/j.1749-6632.2009.05236.x.

Extracellular matrix genes as hypoxia-inducible targets.

Myllyharju J, Schipani E Cell Tissue Res. 2009; 339(1):19-29.

PMID: 19662436 PMC: 3074490. DOI: 10.1007/s00441-009-0841-7.

References

Papandreou I, Lim A, Laderoute K, Denko N . Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3, and BNIP3L. Cell Death Differ. 2008; 15(10):1572-81. DOI: 10.1038/cdd.2008.84. View

Settembre C, Arteaga-Solis E, McKee M, de Pablo R, Al Awqati Q, Ballabio A . Proteoglycan desulfation determines the efficiency of chondrocyte autophagy and the extent of FGF signaling during endochondral ossification. Genes Dev. 2008; 22(19):2645-50. PMC: 2559909. DOI: 10.1101/gad.1711308. View

Vajo Z, Francomano C, Wilkin D . The molecular and genetic basis of fibroblast growth factor receptor 3 disorders: the achondroplasia family of skeletal dysplasias, Muenke craniosynostosis, and Crouzon syndrome with acanthosis nigricans. Endocr Rev. 2000; 21(1):23-39. DOI: 10.1210/edrv.21.1.0387. View

Knudson C, Knudson W . Cartilage proteoglycans. Semin Cell Dev Biol. 2001; 12(2):69-78. DOI: 10.1006/scdb.2000.0243. View

Schipani E, RYAN H, Didrickson S, Kobayashi T, Knight M, Johnson R . Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival. Genes Dev. 2001; 15(21):2865-76. PMC: 312800. DOI: 10.1101/gad.934301. View

Liu Z, Xu J, Colvin J, Ornitz D . Coordination of chondrogenesis and osteogenesis by fibroblast growth factor 18. Genes Dev. 2002; 16(7):859-69. PMC: 186326. DOI: 10.1101/gad.965602. View

Karsenty G, Wagner E . Reaching a genetic and molecular understanding of skeletal development. Dev Cell. 2002; 2(4):389-406. DOI: 10.1016/s1534-5807(02)00157-0. View

Ornitz D, Marie P . FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease. Genes Dev. 2002; 16(12):1446-65. DOI: 10.1101/gad.990702. View

Karsenty G . The complexities of skeletal biology. Nature. 2003; 423(6937):316-8. DOI: 10.1038/nature01654. View

10.

Kronenberg H . Developmental regulation of the growth plate. Nature. 2003; 423(6937):332-6. DOI: 10.1038/nature01657. View

11.

Zelzer E, Olsen B . The genetic basis for skeletal diseases. Nature. 2003; 423(6937):343-8. DOI: 10.1038/nature01659. View

12.

Dierks T, Schmidt B, Borissenko L, Peng J, Preusser A, Mariappan M . Multiple sulfatase deficiency is caused by mutations in the gene encoding the human C(alpha)-formylglycine generating enzyme. Cell. 2003; 113(4):435-44. DOI: 10.1016/s0092-8674(03)00347-7. View

13.

Cosma M, Pepe S, Annunziata I, Newbold R, Grompe M, Parenti G . The multiple sulfatase deficiency gene encodes an essential and limiting factor for the activity of sulfatases. Cell. 2003; 113(4):445-56. DOI: 10.1016/s0092-8674(03)00348-9. View

14.

Levine B, Klionsky D . Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev Cell. 2004; 6(4):463-77. DOI: 10.1016/s1534-5807(04)00099-1. View

15.

Olsen B . Role of cartilage collagens in formation of the skeleton. Ann N Y Acad Sci. 1996; 785:124-30. DOI: 10.1111/j.1749-6632.1996.tb56250.x. View

16.

Shintani T, Klionsky D . Autophagy in health and disease: a double-edged sword. Science. 2004; 306(5698):990-5. PMC: 1705980. DOI: 10.1126/science.1099993. View

17.

Provot S, Schipani E . Molecular mechanisms of endochondral bone development. Biochem Biophys Res Commun. 2005; 328(3):658-65. DOI: 10.1016/j.bbrc.2004.11.068. View

18.

Farach-Carson M, Hecht J, Carson D . Heparan sulfate proteoglycans: key players in cartilage biology. Crit Rev Eukaryot Gene Expr. 2005; 15(1):29-48. DOI: 10.1615/critreveukaryotgeneexpr.v15.i1.30. View

19.

Lefebvre V, Smits P . Transcriptional control of chondrocyte fate and differentiation. Birth Defects Res C Embryo Today. 2005; 75(3):200-12. DOI: 10.1002/bdrc.20048. View

20.

Sardiello M, Annunziata I, Roma G, Ballabio A . Sulfatases and sulfatase modifying factors: an exclusive and promiscuous relationship. Hum Mol Genet. 2005; 14(21):3203-17. DOI: 10.1093/hmg/ddi351. View