Reaching a Genetic and Molecular Understanding of Skeletal Development

Overview

Journal Dev Cell

Publisher Cell Press

Specialties Cell Biology
Reproductive Medicine

Date 2002 Apr 24

PMID 11970890

Citations 530

Authors

Gerard Karsenty

Erwin F Wagner

Affiliations

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Abstract

In the last ten years, we have made considerable progress in our genetic and molecular understanding of all aspects of skeletal development, chondrogenesis, joint formation, and osteogenesis. This review addresses the role of the principal growth factors and transcription factors affecting these different processes and presents, in several cases, the genetic cascade leading to cell differentiation.

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