The Ras Homolog Rhes Affects Dopamine D1 and D2 Receptor-mediated Behavior in Mice

Overview

Journal Neuroreport

Specialty Neurology

Date 2008 Oct 11

PMID 18845937

Citations 17

Authors

Gabriel C Quintero

Daniela Spano

Gerald J Lahoste

Laura M Harrison

Affiliations

Soon will be listed here.

Abstract

Dopamine activates five different receptor subtypes and a complex array of intracellular signaling pathways. Rhes is a striatally expressed guanidine triphosphate-binding protein involved in dopamine signaling. Here we have used mutant mice to test whether Rhes (Ras homolog enriched in striatum) is involved in D1 and D2 dopamine receptor-mediated behaviors. Rhes was not necessary for the expression of normal D1/D2 receptor synergism, as measured by apomorphine-induced stereotypy. The stereotypic responses to D1/D2 costimulation and to D2 stimulation alone were significantly increased in mice lacking Rhes, but D1 receptor-mediated grooming was reduced in these mice. These results suggest that Rhes is normally inhibitory to behaviors induced by D1/D2 receptor costimulation and by D2 receptor stimulation alone. Rhes, however, seems to facilitate the D1-specific behavior of grooming.

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