Laura M Harrison
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Explore the profile of Laura M Harrison including associated specialties, affiliations and a list of published articles.
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12
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122
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Recent Articles
1.
Weiss G, Harrison L, Jiang Z, Nielsen A, Feygin M, Nguyen S, et al.
bioRxiv
. 2024 Aug;
PMID: 39211088
Noradrenergic afferents to hypothalamic corticotropin releasing hormone (CRH) neurons provide a major excitatory drive for somatic stress activation of the hypothalamic-pituitary-adrenal (HPA) axis. We showed that glucocorticoids rapidly desensitize CRH...
2.
Harrison L, Tasker J
Curr Opin Endocr Metab Res
. 2023 Dec;
26.
PMID: 38075196
Glucocorticoids exert pleiotropic effects either by a relatively slow mechanism involving binding to cytosolic/nuclear receptors and regulation of gene expression or by rapid activation of a putative membrane receptor and...
3.
Jiang Z, Chen C, Weiss G, Fu X, Stelly C, Sweeten B, et al.
Cell Rep
. 2022 Oct;
41(3):111509.
PMID: 36261014
Noradrenergic afferents to hypothalamic corticotropin releasing hormone (CRH) neurons provide a major excitatory drive to the hypothalamic-pituitary-adrenal (HPA) axis via α1 adrenoreceptor activation. Noradrenergic afferents are recruited preferentially by somatic,...
4.
Di S, Jiang Z, Wang S, Harrison L, Castro-Echeverry E, Stuart T, et al.
eNeuro
. 2019 Jul;
6(4).
PMID: 31300543
Magnocellular neuroendocrine cells (MNCs) of the hypothalamus play a critical role in the regulation of fluid and electrolyte homeostasis. They undergo a dramatic structural and functional plasticity under sustained hyperosmotic...
5.
He Y, Cornelissen-Guillaume G, He J, Kastin A, Harrison L, Pan W
Chronobiol Int
. 2016 Apr;
33(5):553-60.
PMID: 27078501
Autophagy is essential for normal cellular survival and activity. Circadian rhythms of autophagy have been studied in several peripheral organs but not yet reported in the brain. Here, we measured...
6.
Harrison L, Lahoste G
Exp Cell Res
. 2013 Apr;
319(15):2310-5.
PMID: 23583659
Rhes is a small GTPase whose expression is highly enriched in striatum. It shares homology with Ras proteins, but also contains a C-terminal extension, thus suggesting additional functions. Signaling by...
7.
Harrison L
Cell Mol Neurobiol
. 2012 Mar;
32(6):907-18.
PMID: 22450871
Rhes, the Ras Homolog Enriched in Striatum, is a GTP-binding protein whose gene was discovered during a screen for mRNAs preferentially expressed in rodent striatum. This 266 amino acid protein...
8.
Harrison L, He Y
J Neurosci Res
. 2011 Mar;
89(6):874-82.
PMID: 21374700
The GTP binding proteins Rhes and AGS1/Dexras1 define a subfamily of the Ras superfamily and have been shown to affect signaling by G-protein-coupled receptors. We tested the effects of both...
9.
Lee F, Baiamonte B, Spano D, Lahoste G, Soignier R, Harrison L
Neurosci Lett
. 2010 Dec;
489(3):182-6.
PMID: 21163334
Rhes, the Ras Homolog Enriched in Striatum, is an intermediate-size GTP binding protein. Although its full functions are not yet known, it has been shown to affect signaling and behaviors...
10.
Harrison L, Lahoste G, Ruskin D
Brain Res
. 2008 Oct;
1245:16-25.
PMID: 18929545
Rhes is one of several signaling molecules preferentially expressed in the striatum. This GTP-binding protein affects dopamine-mediated signaling and behavior. Denervating the striatum of its dopaminergic inputs in adulthood reduces...