Progress on Potential Strategies to Target Brain Tumor Stem Cells

Overview

Journal Cell Mol Neurobiol

Publisher Springer

Specialties Cell Biology
Molecular Biology
Neurology

Date 2008 Sep 11

PMID 18781384

Citations 7

Authors

Xing-Gang Mao

Xiang Zhang

Hai-ning Zhen

Affiliations

Soon will be listed here.

Abstract

The identification of brain tumor stem cells (BTSCs) leads to promising progress on brain tumor treatment. For some brain tumors, BTSCs are the driving force of tumor growth and the culprits that make tumor revive and resistant to radiotherapy and chemotherapy. Therefore, it is specifically significant to eliminate BTSCs for treatment of brain tumors. There are considerable similarities between BTSCs and normal neural stem cells (NSCs), and diverse aspects of BTSCs have been studied to find potential targets that can be manipulated to specifically eradicate BTSCs without damaging normal NSCs, including their surface makers, surrounding niche, and aberrant signaling pathways. Many strategies have been designed to kill BTSCs, and some of them have reached, or are approaching, effective therapeutic results. Here, we will focus on advantages in the issue of BTSCs and emphasize on potential therapeutic strategies targeting BTSCs.

Citing Articles

The Role of Hypoxia and Cancer Stem Cells in Development of Glioblastoma.

Shi T, Zhu J, Zhang X, Mao X Cancers (Basel). 2023; 15(9).

PMID: 37174078 PMC: 10177528. DOI: 10.3390/cancers15092613.

Human Glioma Cells Therapy Using ATRA-Induced Differentiation Method to Promote the Inhibitive Effect of TMZ and CCDP.

Li X, Zou Z, Ma E, Feng S, Han S J Healthc Eng. 2021; 2021:6717582.

PMID: 34745507 PMC: 8570852. DOI: 10.1155/2021/6717582.

Hypoxia Regulated Gene Network in Glioblastoma Has Special Algebraic Topology Structures and Revealed Communications Involving Warburg Effect and Immune Regulation.

Mao X, Xue X, Wang L, Wang L, Li L, Zhang X Cell Mol Neurobiol. 2019; 39(8):1093-1114.

PMID: 31203532 PMC: 11452227. DOI: 10.1007/s10571-019-00704-5.

Exosomes from Dendritic Cells Loaded with Chaperone-Rich Cell Lysates Elicit a Potent T Cell Immune Response Against Intracranial Glioma in Mice.

Bu N, Wu H, Zhang G, Zhan S, Zhang R, Sun H J Mol Neurosci. 2015; 56(3):631-43.

PMID: 25680514 DOI: 10.1007/s12031-015-0506-9.

LGR5 is a proneural factor and is regulated by OLIG2 in glioma stem-like cells.

Mao X, Song S, Xue X, Yan M, Wang L, Lin W Cell Mol Neurobiol. 2013; 33(6):851-65.

PMID: 23793848 PMC: 11497887. DOI: 10.1007/s10571-013-9951-6.

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