Minimization of Intermediate Concentrations As a Suggested Optimality Principle for Biochemical Networks. II. Time Hierarchy, Enzymatic Rate Laws, and Erythrocyte Metabolism

Overview

Journal J Math Biol

Date 1991 Jan 1

PMID 1875162

Citations 17

Authors

S Schuster

R Schuster

R Heinrich

Affiliations

Soon will be listed here.

Abstract

The multiobjective problem of minimizing all intermediate concentrations is solved for a model of glycolysis, the pentose monophosphate shunt and the glutathione system in human erythrocytes. It turns out that one solution out of four obtained corresponds qualitatively to the real system. Furthermore, it is shown that for any reaction system, the mentioned optimality principle implies distinct time hierarchy in that some reactions are infinitely fast and subsist in quasi-equilibrium. Finally, the relationships to the standard method of deriving enzymatic rate laws are discussed.

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