Factors Influencing Cell Fatty Acid Composition and A40926 Antibiotic Complex Production in Nonomuraea Sp. ATCC 39727

Overview

Journal J Ind Microbiol Biotechnol

Publisher Oxford University Press

Specialty Biotechnology

Date 2008 Jul 25

PMID 18651189

Citations 8

Authors

Srdjan Jovetic

Marina Feroggio

Flavia Marinelli

Giancarlo Lancini

Affiliations

Soon will be listed here.

Abstract

A40926 is a glycopeptide antibiotic complex consisting of several structurally related factors. It is produced by fermentation of Nonomuraea sp. ATCC 39727 and the complex components differ in the structure of the fatty acid moiety linked to the aminoglucuronic acid unit. In previous work, we observed that the production of single factors in glycopeptide antibiotic complexes could be selectively enhanced by the addition of suitable precursors to the culture medium. In this contribution, we examine the effects of branched amino acid addition to fermentation of Nonomuraea sp. in a chemically defined minimal medium. The changes in the composition of cell fatty acids correlate to the fatty acid distribution within the A40926 complex in diverse cultivation conditions. Nonomuraea sp. prefers isobutyric, butyric and propionic acids as initiators of fatty acid biosynthesis. The relative amount of the produced fatty acids is significantly influenced by the availability of intermediates or final products from the amino acid catabolic pathways. Antibiotic complex composition closely reflects the cell fatty acid pattern, in agreement with the assumption that the antibiotic fatty acid moieties are synthesized by shortening the chain of cell fatty acids.

Citing Articles

Cross-Talking of Pathway-Specific Regulators in Glycopeptide Antibiotics (Teicoplanin and A40926) Production.

Andreo-Vidal A, Yushchuk O, Marinelli F, Binda E Antibiotics (Basel). 2023; 12(4).

PMID: 37107003 PMC: 10135024. DOI: 10.3390/antibiotics12040641.

Redirection of acyl donor metabolic flux for lipopeptide A40926B0 biosynthesis.

Xia T, Chen X, Liu Y, Scharf D, Zhao Q, Li Y Microb Biotechnol. 2022; 15(6):1852-1866.

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Production enhancement of the glycopeptide antibiotic A40926 by an engineered Nonomuraea gerenzanensis strain.

Yan B, Gao W, Tian L, Wang S, Dong H Biotechnol Lett. 2021; 44(2):259-269.

PMID: 34826003 DOI: 10.1007/s10529-021-03210-1.

Complex Regulatory Networks Governing Production of the Glycopeptide A40926.

Alduina R, Sosio M, Donadio S Antibiotics (Basel). 2018; 7(2).

PMID: 29621136 PMC: 6022936. DOI: 10.3390/antibiotics7020030.

Antibacterial Discovery and Development: From Gene to Product and Back.

Fedorenko V, Genilloud O, Horbal L, Marcone G, Marinelli F, Paitan Y Biomed Res Int. 2015; 2015:591349.

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