Complex Regulatory Networks Governing Production of the Glycopeptide A40926

Overview

Journal Antibiotics (Basel)

Specialty Pharmacology

Date 2018 Apr 6

PMID 29621136

Citations 8

Authors

Rosa Alduina

Margherita Sosio

Stefano Donadio

Affiliations

Soon will be listed here.

Abstract

Glycopeptides (GPAs) are an important class of antibiotics, with vancomycin and teicoplanin being used in the last 40 years as drugs of last resort to treat infections caused by Gram-positive pathogens, including methicillin-resistant . A few new GPAs have since reached the market. One of them is dalbavancin, a derivative of A40926 produced by the actinomycete sp. ATCC 39727, recently classified as . This review summarizes what we currently know on the multilevel regulatory processes governing production of the glycopeptide A40926 and the different approaches used to increase antibiotic yields. Some nutrients, e.g., valine, l-glutamine and maltodextrin, and some endogenous proteins, e.g., Dbv3, Dbv4 and RpoB, have a positive role on A40926 biosynthesis, while other factors, e.g., phosphate, ammonium and Dbv23, have a negative effect. Overall, the results available so far point to a complex regulatory network controlling A40926 in the native producing strain.

Citing Articles

The Impact of Heterologous Regulatory Genes from Lipodepsipeptide Biosynthetic Gene Clusters on the Production of Teicoplanin and A40926.

Zhukrovska K, Binda E, Fedorenko V, Marinelli F, Yushchuk O Antibiotics (Basel). 2024; 13(2).

PMID: 38391501 PMC: 10886168. DOI: 10.3390/antibiotics13020115.

Cross-Talking of Pathway-Specific Regulators in Glycopeptide Antibiotics (Teicoplanin and A40926) Production.

Andreo-Vidal A, Yushchuk O, Marinelli F, Binda E Antibiotics (Basel). 2023; 12(4).

PMID: 37107003 PMC: 10135024. DOI: 10.3390/antibiotics12040641.

Establishment of a visual gene knockout system based on CRISPR/Cas9 for the rare actinomycete Nonomuraea gerenzanensis.

Tian L, Yan B, Huo D, Sun W, Cui S, Li X Biotechnol Lett. 2023; 45(3):401-410.

PMID: 36650342 DOI: 10.1007/s10529-023-03347-1.

Production enhancement of the glycopeptide antibiotic A40926 by an engineered Nonomuraea gerenzanensis strain.

Yan B, Gao W, Tian L, Wang S, Dong H Biotechnol Lett. 2021; 44(2):259-269.

PMID: 34826003 DOI: 10.1007/s10529-021-03210-1.

Genomic-Led Discovery of a Novel Glycopeptide Antibiotic by DSM 45129.

Yushchuk O, Vior N, Andreo-Vidal A, Berini F, Ruckert C, Busche T ACS Chem Biol. 2021; 16(5):915-928.

PMID: 33913701 PMC: 8291499. DOI: 10.1021/acschembio.1c00170.

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