Production of the Glycopeptide Antibiotic A40926 by Nonomuraea Sp. ATCC 39727: Influence of Medium Composition in Batch Fermentation

Overview

Journal J Ind Microbiol Biotechnol

Publisher Oxford University Press

Specialty Biotechnology

Date 2003 Apr 11

PMID 12687487

Citations 14

Authors

Nina Gunnarsson

Per Bruheim

Jens Nielsen

Affiliations

Soon will be listed here.

Abstract

Nonomuraea sp. ATCC 39727 is a novel actinomycete species and the producer of A40926, a glycopeptide antibiotic structurally similar to teichoplanin. In the present study, a defined minimal medium was designed for Nonomuraea fermentation. The influence of initial phosphate, glucose and ammonium concentrations on antibiotic productivity was investigated in batch fermentation and the effect of glucose limitation was studied in fed-batch fermentation. It was found that low initial concentrations of phosphate and ammonium are beneficial for A40926 production and that productivity is not enhanced during glucose limitation. Furthermore, the initiation of A40926 production was not governed by residual ammonium and phosphate concentrations, although the level of these nutrients strongly influenced A40926 production rates and final titers.

Citing Articles

Cross-Talking of Pathway-Specific Regulators in Glycopeptide Antibiotics (Teicoplanin and A40926) Production.

Andreo-Vidal A, Yushchuk O, Marinelli F, Binda E Antibiotics (Basel). 2023; 12(4).

PMID: 37107003 PMC: 10135024. DOI: 10.3390/antibiotics12040641.

Establishment of a visual gene knockout system based on CRISPR/Cas9 for the rare actinomycete Nonomuraea gerenzanensis.

Tian L, Yan B, Huo D, Sun W, Cui S, Li X Biotechnol Lett. 2023; 45(3):401-410.

PMID: 36650342 DOI: 10.1007/s10529-023-03347-1.

Production enhancement of the glycopeptide antibiotic A40926 by an engineered Nonomuraea gerenzanensis strain.

Yan B, Gao W, Tian L, Wang S, Dong H Biotechnol Lett. 2021; 44(2):259-269.

PMID: 34826003 DOI: 10.1007/s10529-021-03210-1.

The complete 12 Mb genome and transcriptome of Nonomuraea gerenzanensis with new insights into its duplicated "magic" RNA polymerase.

DArgenio V, Petrillo M, Pasanisi D, Pagliarulo C, Colicchio R, Tala A Sci Rep. 2017; 6(1):18.

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Molecular characterization of forest soil based Paenibacillus elgii and optimization of various culture conditions for its improved antimicrobial activity.

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