Molecular Signatures of Metastasis in Head and Neck Cancer

Overview

Journal Head Neck

Specialties General Surgery
Oncology

Date 2008 Jul 22

PMID 18642293

Citations 16

Authors

Stefano Colella

Kristy L Richards

Linda L Bachinski

Keith A Baggerly

Spiridon Tsavachidis

James C Lang

David E Schuller

Ralf Krahe

Affiliations

Soon will be listed here.

Abstract

Background: Metastases are the primary cause of cancer treatment failure and death, yet metastatic mechanisms remain incompletely understood.

Methods: We studied the molecular basis of head and neck cancer metastasis by transcriptionally profiling 70 samples from 27 patients-matching normal adjacent tissue, primary tumor, and cervical lymph node metastases.

Results: We identified tumor-associated expression signatures common to both primary tumors and metastases. Use of matching metastases revealed an additional 46 dysregulated genes associated solely with head and neck cancer metastasis. However, despite being metastasis-specific in our sample set, these 46 genes are concordant with genes previously discovered in primary tumors that metastasized.

Conclusions: Although our data and related studies show that most of the metastatic potential appears to be inherent to the primary tumor, they are also consistent with the notion that a limited number of additional clonal changes are necessary to yield the final metastatic cell(s), albeit in a variable temporal order.

Citing Articles

Mutated HRAS Activates YAP1-AXL Signaling to Drive Metastasis of Head and Neck Cancer.

Jagadeeshan S, Prasad M, Badarni M, Ben-Lulu T, Liju V, Mathukkada S Cancer Res. 2023; 83(7):1031-1047.

PMID: 36753744 PMC: 10073343. DOI: 10.1158/0008-5472.CAN-22-2586.

Comprehensive gene cluster analysis of head and neck squamous cell carcinoma TCGA RNA-seq data defines B cell immunity-related genes as a robust survival predictor.

Feng X, Zhang T, Chou J, Liu L, Miller L, Sullivan C Head Neck. 2021; 44(2):443-452.

PMID: 34841601 PMC: 8766919. DOI: 10.1002/hed.26944.

Comprehensive Exome Analysis of Immunocompetent Metastatic Head and Neck Cancer Models Reveals Patient Relevant Landscapes.

Li H, Ngan H, Liu Y, Chan H, Poon P, Yeung C Cancers (Basel). 2020; 12(10).

PMID: 33053752 PMC: 7601118. DOI: 10.3390/cancers12102935.

Clinical, pathophysiologic, and genomic analysis of the outcomes of primary head and neck malignancy after pulmonary metastasectomy.

Lu H, Hsieh C, Yeh C, Yeh Y, Wu C, Wang F Sci Rep. 2019; 9(1):12913.

PMID: 31501464 PMC: 6733860. DOI: 10.1038/s41598-019-49212-y.

The Integration of a Three-Dimensional Spheroid Cell Culture Operation in a Circulating Tumor Cell (CTC) Isolation and Purification Process: A Preliminary Study of the Clinical Significance and Prognostic Role of the CTCs Isolated from the Blood....

Liao C, Hsieh C, Hung F, Wang H, Chou W, Wu M Cancers (Basel). 2019; 11(6).

PMID: 31174311 PMC: 6627984. DOI: 10.3390/cancers11060783.

References

Clark E, Golub T, Lander E, Hynes R . Genomic analysis of metastasis reveals an essential role for RhoC. Nature. 2000; 406(6795):532-5. DOI: 10.1038/35020106. View

Hahn W, Weinberg R . Rules for making human tumor cells. N Engl J Med. 2002; 347(20):1593-603. DOI: 10.1056/NEJMra021902. View

Pramana J, Pimentel N, Hofland I, Wessels L, van Velthuysen M, Atsma D . Heterogeneity of gene expression profiles in head and neck cancer. Head Neck. 2007; 29(12):1083-9. DOI: 10.1002/hed.20621. View

Nam S, Clair T, Campo C, Lee H, Liotta L, Stracke M . Autotaxin (ATX), a potent tumor motogen, augments invasive and metastatic potential of ras-transformed cells. Oncogene. 2000; 19(2):241-7. DOI: 10.1038/sj.onc.1203263. View

Weigelt B, Glas A, Wessels L, Witteveen A, Peterse J, Vant Veer L . Gene expression profiles of primary breast tumors maintained in distant metastases. Proc Natl Acad Sci U S A. 2003; 100(26):15901-5. PMC: 307665. DOI: 10.1073/pnas.2634067100. View

ODonnell R, Kupferman M, Wei S, Singhal S, Weber R, OMalley B . Gene expression signature predicts lymphatic metastasis in squamous cell carcinoma of the oral cavity. Oncogene. 2004; 24(7):1244-51. DOI: 10.1038/sj.onc.1208285. View

Sotiriou C, Lothaire P, Dequanter D, Cardoso F, Awada A . Molecular profiling of head and neck tumors. Curr Opin Oncol. 2004; 16(3):211-4. DOI: 10.1097/00001622-200405000-00003. View

Chung C, Parker J, Karaca G, Wu J, Funkhouser W, Moore D . Molecular classification of head and neck squamous cell carcinomas using patterns of gene expression. Cancer Cell. 2004; 5(5):489-500. DOI: 10.1016/s1535-6108(04)00112-6. View

Liotta L, Kohn E . The microenvironment of the tumour-host interface. Nature. 2001; 411(6835):375-9. DOI: 10.1038/35077241. View

10.

Mao L, Hong W, Papadimitrakopoulou V . Focus on head and neck cancer. Cancer Cell. 2004; 5(4):311-6. DOI: 10.1016/s1535-6108(04)00090-x. View

11.

Matrisian L, Cunha G, Mohla S . Epithelial-stromal interactions and tumor progression: meeting summary and future directions. Cancer Res. 2001; 61(9):3844-6. View

12.

Hunter K, Thurlow J, Fleming J, Drake P, Vass J, Kalna G . Divergent routes to oral cancer. Cancer Res. 2006; 66(15):7405-13. DOI: 10.1158/0008-5472.CAN-06-0186. View

13.

Ramaswamy S, Ross K, Lander E, Golub T . A molecular signature of metastasis in primary solid tumors. Nat Genet. 2002; 33(1):49-54. DOI: 10.1038/ng1060. View

14.

J van t Veer L, Dai H, van de Vijver M, He Y, Hart A, Mao M . Gene expression profiling predicts clinical outcome of breast cancer. Nature. 2002; 415(6871):530-6. DOI: 10.1038/415530a. View

15.

Hassan K, Ang K, El-Naggar A, Story M, Lee J, Liu D . Cyclin B1 overexpression and resistance to radiotherapy in head and neck squamous cell carcinoma. Cancer Res. 2002; 62(22):6414-7. View

16.

Irizarry R, Hobbs B, Collin F, Beazer-Barclay Y, Antonellis K, Scherf U . Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics. 2003; 4(2):249-64. DOI: 10.1093/biostatistics/4.2.249. View

17.

Lemon W, Palatini J, Krahe R, Wright F . Theoretical and experimental comparisons of gene expression indexes for oligonucleotide arrays. Bioinformatics. 2002; 18(11):1470-6. DOI: 10.1093/bioinformatics/18.11.1470. View

18.

Kyriazanos I, Tachibana M, Dhar D, Shibakita M, Ono T, Kohno H . Expression and prognostic significance of S100A2 protein in squamous cell carcinoma of the esophagus. Oncol Rep. 2002; 9(3):503-10. View

19.

Dong Y, Sui L, Watanabe Y, Sugimoto K, Tokuda M . Clinical relevance of cyclin B1 overexpression in laryngeal squamous cell carcinoma. Cancer Lett. 2002; 177(1):13-9. DOI: 10.1016/s0304-3835(01)00770-4. View

20.

Buckhaults P . Gene expression determinants of clinical outcome. Curr Opin Oncol. 2005; 18(1):57-61. DOI: 10.1097/01.cco.0000198022.76476.b2. View