Structure and Function of HCV IRES Domains

Overview

Journal Virus Res

Specialty Microbiology

Date 2008 Jul 22

PMID 18638512

Citations 117

Authors

Peter J Lukavsky

Affiliations

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Abstract

The HCV IRES is a highly structured RNA which mediates cap-independent translation initiation in higher eukaryotes. This function is encoded in conserved structural motifs in the two major domains of HCV and HCV-like IRESs, which play crucial and distinct roles along the initiation pathway. In this review, I discuss structural features of IRES domains and how these RNA motifs function as RNA-based initiation factors to form 48S initiation complexes and 80S ribosomes with only a subset of canonical, protein-based eukaryotic initiation factors.

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