RNA-Binding Proteins As Regulators of Internal Initiation of Viral MRNA Translation

Overview

Journal Viruses

Publisher MDPI

Specialty Microbiology

Date 2022 Feb 26

PMID 35215780

Authors

Brenda Lopez-Ulloa

Yazmin Fuentes

Magdalena S Pizarro-Ortega

Marcelo Lopez-Lastra

Affiliations

Soon will be listed here.

Abstract

Viruses are obligate intracellular parasites that depend on the host's protein synthesis machinery for translating their mRNAs. The viral mRNA (vRNA) competes with the host mRNA to recruit the translational machinery, including ribosomes, tRNAs, and the limited eukaryotic translation initiation factor (eIFs) pool. Many viruses utilize non-canonical strategies such as targeting host eIFs and RNA elements known as internal ribosome entry sites (IRESs) to reprogram cellular gene expression, ensuring preferential translation of vRNAs. In this review, we discuss vRNA IRES-mediated translation initiation, highlighting the role of RNA-binding proteins (RBPs), other than the canonical translation initiation factors, in regulating their activity.

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