Location, Location, Location...site-specific GPCR Phosphorylation Offers a Mechanism for Cell-type-specific Signalling

Overview

Journal Trends Pharmacol Sci

Specialty Pharmacology

Date 2008 Jul 9

PMID 18606460

Citations 152

Authors

Andrew B Tobin

Adrian J Butcher

Kok Choi Kong

Affiliations

Soon will be listed here.

Abstract

It is now established that most of the approximately 800 G-protein-coupled receptors (GPCRs) are regulated by phosphorylation in a process that results in the recruitment of arrestins, leading to receptor desensitization and the activation of arrestin-dependent processes. This generalized view of GPCR regulation, however, does not provide an adequate mechanism for the control of tissue-specific GPCR signalling. Here, we review the evidence that GPCR phosphorylation is, in fact, a flexible and dynamic regulatory process in which GPCRs are phosphorylated in a unique manner that is associated with the cell type in which the receptor is expressed. In this scenario, phosphorylation offers a mechanism of regulating the signalling outcome of GPCRs that can be tailored to meet a specific physiological role.

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